No images? Click here What's new? Recent additions to DISCOVERY® AntibodiesDiscovery® Antibodies is the catalogue range of antibodies from the revered UK manufacturer Cambridge Research Biochemicals. We have a well-established custom antibody generation operation and we are the second oldest custom peptide manufacturer in the world. Unlike many catalogue antibody and peptide suppliers, our antibodies and antigen peptides are designed against sought after targets and manufactured by us in the United Kingdom. Get in touch if there are any antibodies you can't source as we're always looking for new targets to expand our catalogue range. The histone proteins...Histones are a family of proteins which help organise and condense the DNA. Four core histone proteins (H2A, H2B, H3 and H4) make up the histone core around which DNA is wound to form the nucleosome. Histone proteins are able to control the level of compaction of the DNA to facilitate gene expression or silencing. The tail region of the four core histone proteins have the ability to be highly modified by a wide range of histone modifying enzymes. The presence of histone variants as well as mutations in histone proteins can have profound effects on DNA organisation and gene expression....read more |