Wednesday, December 16

Dear Sir or Madam,

Check out the latest news from antibodies-online:

Now, it's faster and easier than ever to identify PD-1 pathway inhibitors

Programmed Cell Death 1 (PD-1) is a pivotal immune checkpoint, and a negative regulator of immune response. 

Activation of PD-1 by its ligand PD-L1 suppresses autoimmunity by preventing inappropriate activation of T-cells. Tumors frequently subvert this mechanism to avoid immune surveillance, and PD-1 pathway inhibitors have shown some promise as anti-cancer therapeutic agents. 

ABIN2762509, the ACROBiosystems PD-1/PD-L1 inhibitor screening pair may be used in a functional immunoassay to screen for candidate molecules that inhibit PD-1/PD-L1 interaction and block PD-1 pathway activation.

The ACROBiosystems PD-1 inhibitor screening pair is a better way to identify PD-1 pathway inhibitors:

• Fast & Efficient:  Pre-labeled components are included in the kit. Following plate coating, the PD-1 inhibitor screening assay can be completed in just a few hours.
• Reliable & Authentic:  Recombinant PD-1 and PD-L1 are expressed in human (HEK293) cells to ensure accurate folding and post-translational modification.
• Simple: The PD-1 inhibitor screening assay is a simple sandwich-format functional ELISA, completed in 4 easy steps. Labeled, recombinant ligand/receptor pair, and a PD-1 neutralizing control antibody are included in the assay kit.
• Reproducible: Labeled recombinant PD-1 and PD-L1 are produced to stringent quality control standards, with minimal lot-to-lot variation for long term reproducibility and consistency in large scale experiments.

"Each of us have things and thoughts and descriptions of an amazing universe in our possession that kings in the 17th Century would have gone to war to possess."- Kary Banks Mullis, American Biochemist and Nobel Laureate