Hypha Discovery: metabolite synthesis and purification specialistsWHAT'S NEWN-glucuronides: on the rise? We’ve observed an increase in synthesis requests for N-glucuronides over the last few years. We speculate that this may be due to the growing inclusion of nitrogen containing heterocycles in the design of new small molecule drugs, and pan company strategies to reduce CYP metabolism. The situation is further complicated by the high interspecies variability in formation of some N-glucuronides, especially aliphatic tertiary amines and aromatic N-heterocycles. UGT1A4 and UGT2B10 are key enzymes responsible for N-glucuronidation reactions in humans, rates of which can be much higher than in other animals. To compound this, synthesis of N-glucuronides isn’t always straightforward - read about Hypha's solutions to accessing and characterising N-glucuronides here. More great client feedback We've received some more feedback for the excellent work Hypha scientists did to ensure successful completion of a challenging metabolite project for a US pharma client. |