A French group led by Dr. Vincent Descamps has found preliminary evidence suggesting that PCR saliva testing is useful for the detection of herpesvirus reactivation among patients with drug hypersensitivity syndromes such as DIHS/DRESS. The PCR assay used in the study demonstrated shedding of HHV-7, EBV, HHV-6, and CMV. Herpesvirus reactivation, in particular HHV-6, is a hallmark of drug hypersensitivity conditions, and has been shown to contribute to increasingly severe clinical outcomes. The group has now initiated a large therapeutic prospective study to determine the effectiveness of various treatment regimens - including antiviral treatments for patients with betaherpesvirus reactivation - to limit the clinical severity of DIHS/DRESS. READ MORE