Testosterone Therapy May Increase Risk of Adverse Outcomes in Some Men
New Research: Responders to PDE5 Inhibitors Therapy
Men with "significant medical comorbidities" may be at higher risk of death, heart attack, and stroke if they undergo testosterone therapy, American researchers report.
Their study, published in November in the Journal of the American Medical Association (JAMA) involved over 8,700 men who had a coronary angiography between 2005 and 2011. At the time of the angiography, all of the men had testosterone levels below 300 ng/dL.
About 20% of the men had had a previous heart attack, half had diabetes, and over 80% had coronary artery disease.
Fourteen percent of the men started subsequent testosterone therapy, administered by gel, patch, or injection. The remaining men had no testosterone therapy.
At follow up, the researchers found that death, heart attacks, and strokes were more common among men who had taken testosterone.
According to a press-release from JAMA, "The researchers found that the proportion of patients experiencing events 3 years after coronary angiography was 19.9 percent in the no testosterone therapy group (average age, 64 years) and 25.7 percent in the testosterone therapy group (average age, 61 years), for an absolute risk difference of 5.8 percent.”
To learn more about this study, please click here.
2014 Membership Renewal
A new research summary has been posted to the ISSM website.
"Nonresponders, Partial Responders, and Complete Responders to PDE5 Inhibitors Therapy According to IIEF Criteria: Validation of an Anchor-Based Treatment Responder Classification" by May Yang, MPH; Xiao Ni, PhD; Angelina Sontag, PhD; Heather J. Litman, PhD; and Raymond C. Rosen, PhD was published in the Journal of Sexual Medicine in October.
The study addresses the need for clear, standardized definitions that can be used to describe men's response to erectile dysfunction treatment with PDE5 inhibitors. It also discusses ways that clinicians and researchers can use these definitions.
For more details, please click here.
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