For years, CFS researchers have been looking for a pathogenic agent that causes the myriad of symptoms experienced by patients with the condition. However, according to a novel hypothesis from researchers at the Tufts University PTSD neuroimaging laboratory, they may have been looking in the wrong place. The new theory, published this month in Medical Hypotheses, suggests that CFS may be the result of a pathological infection of the vagus nerve. If this low-level “chronic” infection is localized to the vagus nerve it would be undetectable in the plasma, but still able to cause the sensory vagus nerve to send signals to the brain that initiate “sickness behavior,” an involuntary response characterized by fatigue, fever, myalgia, depression, and other symptoms that are often observed in patients with CFS. Although the theory proposes that any neutoropic virus or bacteria could trigger CFS, HHV-6 is at the top of the list. READ MORE