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Latest News from the ISSM - November 13, 2015 Member Login
Vortioxetine May Have Fewer Sexual Side Effects Than Other Antidepressants

Vortioxetine may be a useful alternative for depressed patients coping with treatment-emergent sexual dysfunction, American researchers suggest. 

While many medications are effective for treating depression, some - particularly serotonin-norepinephrine reuptake inhibitors (SNRIs) and selective serotonin reuptake inhibitors (SSRIs) - can have sexual side effects, such as diminished desire, arousal, and orgasm.

Some patients stop taking their medication because of such side effects.

The study involved 447 men and women between the ages of 18 and 55 who were taking an SSRI for a major depressive episode.

The participants stopped their medication and were randomly assigned to take either vortioxetine or escitalopram (another SSRI) for eight weeks. Depression symptoms and sexual function were assessed periodically. 

Overall, patients taking vortioxetine had better sexual outcomes than those taking escitalopram. Depression symptoms for all patients remained stable. 

The study was first published online in August in The Journal of Sexual Medicine. Further details are available here. 

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