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NINDS study finds 38% of MS patients harbor HHV-6 or EBV specific oligoclonal bands

Researchers at the NINDS have published findings that further strengthen the relationship between HHV-6, EBV, and multiple sclerosis.  The report demonstrates that 24% of 37 CSF samples from MS patients had HHV-6 reactive oligoclonal bands (OCBs) and 14% had EBV OCBs, compared to none in patients with other inflammatory neurological diseases (p=0.005). In addition, brain imaging analysis also showed that MS patients with viral DNA detected in the CSF exhibited more brain contrast enhancing lesions (CELs) than those who were virus-negative.  READ MORE

Does HHV-6 infection of the sperm contribute to infertility?

Researchers from Denmark have identified HHV-6A/B in 13.5% of semen samples from 198 sperm donors, a significantly higher prevalence than any other herpesvirus detected in the study.  Interestingly, the group also shows that HHV-6B is able to bind specifically to the acrosome of sperm, suggesting that the virus could be transported to the uterus via this binding mechanism.  READ MORE

New broad-spectrum antiherpesvirus agents identified

Researchers at the University of Alabama at Birmingham have reported that a set of novel methylenecyclopropane (MCP) nucleoside analogs, synthesized by Microbiotix, Inc., have shown increased activity against a broad spectrum of human herpesviruses.  The new agents are derivations of the compound cyclopropavir (CPV), currently in human phase I clinical studies, which has previously been shown to exhibit good antiviral activity against human beta-and gamma-herpes viruses, including HCMV, EBV, HHV-6A, HHV-6B, and HHV-8.  In addition, all but one of the new analogs had potent anti-viral activity against HHV-6B that was greater than that of cidofovir (CDV).  READ MORE