Editor's note

This week, the Nobel Prize for Physiology and Medicine went to scientists James P. Allison and Tasuku Honjo for work that led to new, and often successful, ways of treating cancer. Initially focusing on the machinery of the immune system, they made significant advances to understanding two key proteins that can stop cancer cells from evading our immune defences.

Their early ‘90s findings spurred the development of immunotherapy drugs known as checkpoint inhibitors. These have been dubbed the “fourth pillar” (after surgery, chemotherapy and radiotherapy) to cancer treatment. As Craig Gedye writes, from AFL player Jarryd Roughead to businessman Ron Walker, to former US president Jimmy Carter, anecdotes abound for the activity of immune checkpoint inhibitors in advanced cancers such as melanoma, lung, kidney and bladder and others.

Sasha Petrova

Deputy Editor, Health + Medicine

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Jarryd Roughead was successfully treated with immunotherapy for melanoma. BRENDON THORNE/AAP

How two 1990s discoveries have led to (some) cured cancers, and a Nobel Prize

Craig Gedye, University of Newcastle

In a remarkably short period of time, drugs that harness the power of the immune system, have been used to successfully treat many cancers.

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