Ever since 2003, when the NIH announced the completion of the Human Genome Project – the DNA-encoded instruction manual for the human body – I’ve been waiting for a future in which reading our DNA is a routine part of medicine. But in 2003 that wasn’t possible. The price tag of this first complete genome was $2.7 billion and took 13 years. Not a practical timescale or cost for medicine.

But today things are very different. The cost of sequencing an entire human genome has plummeted to just several thousand dollars, even less at hospitals, universities and large corporations. Today Charles Chiu, professor of laboratory science at the University of California, San Francisco, describes how he is using a superfast method called “metagenomic next-gen sequencing” to analyze the DNA from critically sick patients with confusing symptoms to discover the cause of their illness and provide the best treatment.

Also today, explaining the Fed’s delicate dance on inflation, the psychology of the Quantified Self movement and enduring sexism in sports journalism.

Top story

Decoding all the DNA in a patient’s biological sample can reveal whether an infectious microbe is causing the disease. ktsdesign/Shutterstock.com

Rapid DNA analysis helps diagnose mystery diseases

Charles Chiu, University of California, San Francisco

Superfast DNA analysis is now being used to crack medical mysteries when physicians can't figure out whether an infectious microbe is causing the disease.

Politics + Society

  • What does the Trump administration want from Iran?

    Noah Weisbord, Queen's University, Ontario

    A showdown with Iran showdown over some oil tanker attacks in the Persian Gulf could push the US into its next Mideast war, writes a scholar of military aggression.

Economy + Business

Arts + Culture

Science + Technology

Health + Medicine

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Today’s quote

What I learned from the many people I encountered is that self-tracking is an ambivalent practice.

 

For some, self-tracking means more than self-help

 

Joseph Reagle

Northeastern University

Joseph Reagle
 
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