February 22, 2021

In Case You Missed It:

• Refer to the COVID-19 and MCW Research page to stay up-to-date on changes in research operations related to the current pandemic.
• COVID-19: Information for NIH Applicants and Recipients of NIH Funding
• It's MCW Research Week! The Office of Research is pleased to release the Virtual Research Week Schedule and Digital Event Catalog. Add events to your calendar and review presenter abstracts. Several presenters have included poster files and pre-recorded presentations for browsing anytime. VRW activities will also be recorded for future viewing. For inquires, contact the Office of Research. | Event Catalog
• We Care Fund seeks applications for 2021 Faculty Seed Grants.

Surgery Research Conference Recap, February 10
Hoplon: Percutaneous Treatment of LVAD Thrombosis

David Joyce, MD, MBA
Associate Professor
Division of Cardiothoracic Surgery

Join Us Next Month for Surgery Research Conference
Research Resident Research Update
Wednesday, March 10 | 5 p.m.

GRANT$ Alert

ASCRS Career Development Award
$75,000/year for two years
Proposal due in eBridge: March 8, 2021

The goal of the CDA is to provide young surgeons with the support necessary for the initiation and development of an academic career in colorectal surgery. As opposed to the LPG awards, the CDA focuses on career development and mentorship of the individual rather than solely on the research proposal. The award is intended for the academic investigator demonstrating significant creativity in research relevant to the pathophysiology or management of diseases of the colon, rectum, anus or small bowel.

Office of Research 2021 Competitive Resubmission Funding
Up to $50,000
Proposals Due: March 8, 2021

The Office of Research is pleased to announce an opportunity to provide full-time or full professional effort faculty within the School of Medicine funds to allow faculty members with grant proposals that are scored but not funded to obtain critical preliminary data to support successful resubmission. We will provide funding for research projects specifically designed to strengthen the federal grant applications that have received excellent priority scores but are outside the funding window. NIH R01, VA Merit award, NSF and DOD grants are examples of the types of applications that are eligible for this funding mechanism.

MCW Cancer Center Clinical Concept Award
2-year up to $150,000
Application Due: March 31, 2021

Researchers with relevant research from all areas of science are invited to apply to this RFA. Priority will be given to collaborations between basic or translational science, and population science or epidemiologic researchers who propose to study topics related to understanding or addressing cancer disparities. Inclusion of correlative studies that utilize MCW CC Shared Resources, especially those provided by the GSPMC (NGS such as genomic, transcriptomic and epigenomic sequencing and bioinformatic analysis), are encouraged.

MCW Cancer Center NGS-Based Pilot Projects-Sequencing, Bioinformatics, and Analysis Award
Sequencing through Bioinformatics projects will receive up to $15,000 for GSPMC services
Bioinformatics-only projects will receive up to $5,000 for GSPMC services
Application Due: March 31, 2021

To advance precision oncology and the molecular understanding of cancer, the MCW Cancer Center (CC), in partnership with the Genomic Sciences and Precision Medicine Center (GSPMC), is inviting proposals for small-scale research projects that utilize any combination of the genomic, transcriptomic or epigenomic technologies and bioinformatics platforms available in the GSPMC. Responsive proposals will describe projects that either improve our understanding of cancer initiation, progression or therapeutic resistance or show promise to improve cancer prevention, early detection, diagnosis or treatment.

Office of Research Program Project Formation Grant
$150,000 per year for up to two years
Letter of Intent due (REDCap): March 31, 2021

The Office of Research is pleased to announce an opportunity to provide full-time or full professional effort faculty within the School of Medicine with pilot funding for projects in which multiple laboratories work collaboratively to solve complex biomedical problems. The goal of the funding mechanism is that the research team is positioned to submit a competitive application for a program project or equivalent grant to NIH within 3 years of initiation of this award. Applications will be required to include at least 3 faculty members all collaborating to one overall project goal that will be funded and may also include funding for the development of cores that will be essential for the NIH submission. The application will require that the team describe the proposed structure of the NIH submission and how each of the individual elements will synergize with each other to achieve the goals of the project. Factors that will be considered in the evaluation of these projects will include the human health significance and innovation of the project; expertise and research accomplishments of the researchers; the strength of the research premise; and the need for additional funding to achieve extramural support.

We Care Fund for Medical Innovation and Research 2021 Faculty Seed Grants
$50,000 Promising pilot grant, distributed over 1 year
$100,000 New collaboration grant, distributed over 2 years
Application Due: Friday, April 9, 2021

The mission of the We Care Fund is to use contributions made available by the philanthropic community to support Department of Surgery faculty who are creating innovative therapies and clinical programs that benefit patients in Wisconsin and throughout the world. Proposals should demonstrate the importance of innovation and discovery to advance science and the clinical care of patients. Any level of science is eligible for funding; preference will be given to those proposals that effectively articulate a translational theme even if the bedside application may be in the future. Proposals may include innovative basic science or clinical research projects. Potential for extramural funding will be a consideration for these applications as the goal of We Care is to stimulate preliminary data for a larger NIH (or equivalent) proposal.

Abstracts Alert

American College of Surgeons (ACS) Annual Clinical Congress 2021
October 24-28, 2021, Washington, DC
Abstract Deadline: March 1, 2021

Abstracts or videos may be submitted for the following Clinical Congress programs:

Owen H. Wangensteen Scientific Forum
The Owen H. Wangensteen Scientific Forum offers researchers the opportunity to present the results of their original, basic science, clinical, education, health sciences, and translational research. 

Video-Based Education Sessions
The Video-Based Education Sessions aims to educate surgeons and members of surgical teams in order to improve the care of the surgical patient, as well as safeguard the standards of care in an optimal practice environment.

History of Surgery Poster Session
The History of Surgery Poster Session offers surgical history enthusiasts the opportunity to present on subjects of interest related to the history of the field of surgery and its subspecialties.

The American Society for Artificial Internal Organs (ASAIO) 2021 Annual Conference
June 10-12, 2021, Washington, DC
Abstract Deadline: March 1, 2021

• Abstracts must be written in English.
• If you begin an Abstract you must complete it before the submission deadline of Monday, March 1, 2021 by 11:59pm Eastern Standard Time.
• Review: Abstracts will receive "blind" peer review.
• Publication: Qualified Abstracts received by the deadline that are accepted for presentation at the conference will be published in the Online ASAIO Journal. ASAIO reserves the right to withhold the publication of any Abstract.
• Notification: Acceptance notification will be sent in April 2021 by E-mail from ASAIO Management.
• Presentation: PowerPoint is required for abstracts that are accepted as oral presentations.
• Specific guidelines for PowerPoint presentations will be available on the ASAIO website in January: https://asaio.org/

Southern Thoracic Surgical Association (STSA) Annual Meeting
November 3-6, 2021, Atlanta, GA
Abstract Deadline: April 5, 2021

To submit an abstract, you will need to access the online submission site through X-CD System. Of important note, STSA requires that all abstract authors (primary and co-authors) submit their commercial and financial disclosure information by the abstract submission deadline of April 5, 2020. Co-authors may login and complete their personal commercial relationship form. Only one form is required per author for the meeting.

Society of Black Academic Surgeons (SBAS) Annual Meeting
September 16–19, 2021, St. Louis, MO
Abstract Deadline: April 5, 2021

Abstract submission opened February 15.

Society of Asian Academic Surgeons (SAAS) Annual Meeting
September 23-24, 2021, Baltimore, MD
Abstract Deadline: TBD

Abstract submission for the meeting will open approximately March 1, 2021

Department of Surgery Recent Publications

Neighborhood disadvantage is associated with stable deficits in neurocognitive functioning in traumatically-injured adults. Health & Place (Webb EK; Weis CN; Huggins AA; Parisi EA; Bennett KP; Miskovich T; Krukowski J; deRoon-Cassini TA; Larson CL.)

Venous thromboembolism prophylaxis after pediatric trauma. [Review] Pediatric Surgery International. (Georgeades C; Van Arendonk K; Gourlay D.)

Clinical outcomes following implementation of a management bundle for esophageal atresia with distal tracheoesophageal fistula. Journal of Pediatric Surgery. (Bence CM; Rymeski B; Gadepalli S; Sato TT; Minneci PC; Downard C; Hirschl RB; Amin RA; Burns RC; Cherney-Stafford L; Courtney CM; Deans KJ; Fallat ME; Fraser JD; Grabowski JE; Helmrath MA; Kabre RD; Kohler JE; Landman MP; Lawrence AE; Leys CM; Mak GZ; Port E; Saito JM; Silverberg J; Slidell MB; St Peter SD; Troutt M; Walker S; Wright T; Lal DR; Midwest Pediatric Surgery Consortium.)

Can patients find an Endocrine Surgeon? How hospital websites hide the expertise of these medical professionals. American Journal of Surgery. (Gentry ZL; Ananthasekar S; Yeatts M; Chen H; Dream S.)

Personality Characteristics and Acute Symptom Response Predict Chronic Symptoms After Mild Traumatic Brain Injury. Journal of the International Neuropsychological Society. (Parker HA; Ranson J; McCrea MA; Hoelzle J; deRoon-Cassini T; Nelson LD.)

Impact of Perioperative Blood Transfusions on Outcomes After Hyperthermic Intraperitoneal Chemotherapy: A Propensity-Matched Analysis. Annals of Surgical Oncology. (Kubi B; Nudotor R; Fackche N; Nizam W; Cloyd JM; Grotz TE; Fournier KF; Dineen SP; Powers BD; Veerapong J; Baumgartner JM; Clarke CN; Patel SH; Lambert LA; Abbott DE; Vande Walle KA; Raoof M; Lee B; Maithel SK; Staley CA; Johnston FM; Greer JB.)

Appendectomy Versus Observation for Appendicitis in Neutropenic Children With Cancer. Pediatrics. (Many BT; Lautz TB; Dobrozsi S; Wilkinson KH; Rossoff J; Le-Nguyen A; Dakhallah N; Piche N; Weinschenk W; Cooke-Barker J; Goodhue C; Zamora A; Kim ES; Talbot LJ; Quevedo OG; Murphy AJ; Commander SJ; Tracy ET; Short SS; Meyers RL; Rinehardt HN; Aldrink JH; Heaton TE; Ortiz MV; Baertschiger R; Wong KE; Lapidus-Krol E; Butter A; Davidson J; Stark R; Ramaraj A; Malek M; Mastropolo R; Morgan K; Murphy JT; Janek K; Le HD; Dasgupta R; Lal DR; PEDIATRIC SURGICAL ONCOLOGY RESEARCH COLLABORATIVE.)

Tips for authors of surgical manuscripts from senior reviewers. Surgery. (Malangoni MA; Evans DB; Prinz RA; Hodin RA; Rege R; Harken AH.)

Trends in gastrostomy tube placement with concomitant Nissen fundoplication for infants and young children at Pediatric Tertiary Centers. Pediatric Surgery International. (Bouchard ME; Stewart DH; Hall M; Many BT; Vacek JC; Papastefan S; Van Arendonk K; Abdullah F; Goldstein SD.)

The value of the modern vascular surgeon to the health care system: A report from the Society for Vascular Surgery Valuation Work Group. Journal of Vascular Surgery. (Powell R; Brown K; Davies M; Hart J; Hsu J; Johnson B; Makaroun M; Schanzer A; Shutze W; Weaver F; White J; SVS Valuation Work Group.)

Xanthomatous Dermal Changes in a Patient With Locally Advanced Basal Cell Carcinoma Treated Using Vismodegib. American Journal of Dermatopathology. (Smith SDB; Clarke CN; Clark MA; Harker-Murray AK; Sokumbi O.)

Solid Organ Donor-Recipient Race-matching: Analysis of the United Network for Organ Sharing Database. Transplant International. (LeClaire JM; Smith NJ; Chandratre S; Rein L; Kamalia MA; Kohmoto T; Joyce LD; L D; Joyce.)

An Institutional experience with primary hyperparathyroidism in the elderly over two decades. American Journal of Surgery. (O'Sullivan K; Yen TWF; Doffek K; Dream S; Mazotas I; Evans DB; Wang TS.)

Primary Aortoduodenal Fistula: A Case Report and Current Literature Review. Annals of Vascular Surgery. (Georgeades C; Zarb R; Lake Z; Wood J; Lewis B.)

Epidemiology and outcomes of primary pediatric lung malignancies: Updates from the SEER database. American Journal of Surgery. (Smith NJ; Mukherjee D; Wang Y; Brazauskas R; Nelson AA; Cortina CS.)

Calcified Homograft With Aortic Insufficiency: A Hybrid Alternative Approach to Clamping. Annals of Thoracic Surgery. (Konz MG; Rossi PJ; Rokkas CK.)

Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells. Science Advances. (Wang Y; Wu J; Chen H; Yang Y; Xiao C; Yi X; Shi C; Zhong K; He H; Li Y; Wu Z; Zhou G; Rao Q; Wang X; Zhou X; Lomberk G; Liu B; Zhao J; Ge J; Zhou W; Chu X; Chen C; Zhou X; Wang L; Guan K; Qu L.)

DACC Resting State Functional Connectivity as a Predictor of Pain Symptoms Following Motor Vehicle Crash: A Preliminary Investigation. Journal of Pain. (Fitzgerald JM; Belleau EL; Ehret LE; Trevino C; Brasel KJ; Larson C; deRoon-Cassini T.)

Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. Orphanet Journal Of Rare Diseases. (Chi YI; Stodola TJ; De Assuncao TM; Levrence EN; Tripathi S; Dsouza NR; Mathison AJ; Basel DG; Volkman BF; Smith BC; Lomberk G; Zimmermann MT; Urrutia R.)

Clinical and Radiographic Factors Associated With Failed Renal Angioembolization: Results From the Multi-institutional Genitourinary Trauma Study (Mi-GUTS). Urology. (Armas-Phan M; Keihani S; Agochukwu-Mmonu N; Cohen AJ; Rogers DM; Wang SS; Gross JA; Joyce RP; Hagedorn JC; Voelzke B; Moses RA; Sensenig RL; Selph JP; Gupta S; Baradaran N; Erickson BA; Schwartz I; Elliott SP; Mukherjee K; Smith BP; Santucci RA; Burks FN; Dodgion CM; Carrick MM; Askari R; Majercik S; Nirula R; Myers JB; Breyer BN.)

Identifying Maltreatment in Infants and Young Children Presenting With Fractures: Does Age Matter?. Academic Emergency Medicine. (Mitchell IC; Norat BJ; Auerbach M; Bressler CJ; Como JJ; Escobar MA Jr; Flynn-O'Brien KT; Lindberg DM; Nickoles T; Rosado N; Weeks K; Maguire S.)

Preliminary analysis of the antimicrobial activity of a novel surgical incise drape containing chlorhexidine gluconate against methicillin-resistant Staphylococcus aureus (MRSA) in an in vivo porcine, incisional-wound model. American Journal of Infection Control. (Carty N; Leaper D; Perry L; Edmiston CE Jr.)

Nitric oxide added to the sweep gas of the oxygenator during cardiopulmonary bypass in infants: A pilot randomized controlled trial. Artificial Organs. (Niebler RA; Chiang-Ching H; Daley K; Janecke R; Jobe SM; Mitchell ME; Varner C; Woods K; Scott JP.)

Neutrophil-Derived Myeloperoxidase Facilitates Both the Induction and Elicitation Phases of Contact Hypersensitivity. Frontiers in Immunology. (Strzepa A; Gurski CJ; Dittel LJ; Szczepanik M; Pritchard KA Jr; Dittel BN.)

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