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European Pharmaceutical Review

Lilly presents follow-up data on semagacestat to assist future Alzheimer’s disease research

Lilly has presented data from the first of two Phase III trials of semagacestat. Semagacestat is a gamma secretase inhibitor that had been studied as a potential treatment for Alzheimer’s disease. The results provided patient outcomes from the active treatment portion of the study, and from a modified portion of the study conducted after dosing with semagacestat was stopped....

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More pharmaceutical & life science news:

Roche acquires mtm laboratories AG, expanding offering in cervical cancer testing
Roche has signed an agreement to acquire 100 percent of mtm laboratories AG (mtm), a privately-held company based in Heidelberg, Germany...

Florbetapir “Imaging to Autopsy” study awarded Alzheimer’s Association’s 2011 de Leon Prize in Neuroimaging
The award was presented Saturday to Chris Clark, M.D., co-author of the paper and medical director at Avid Radiopharmaceuticals during the Alzheimer’s Imaging Consortium (AIC)...

VICTRELIS™ (boceprevir), first-in-class oral hepatitis C virus protease inhibitor, approved in the European Union
Merck has announced the approval of VICTRELIS™ (boceprevir) for the treatment of chronic hepatitis C (CHC) genotype 1 infection, in combination with peginterferon alfa and ribavirin, in adult patients with compensated liver disease who are previously untreated or who have failed previous therapy...

New data showed minimal potential for drug interaction between cholesterol drug LIVALO® and a common antiretroviral therapy
Kowa Pharmaceuticals America, Inc. and Eli Lilly and Company have released new study results that investigated the potential interaction of cholesterol drug LIVALO (pitavastatin) 4 mg in healthy volunteers taking the protease inhibitor (PI) combination lopinavir/ritonavir, a fixed dose combination drug for the treatment of HIV infection...

Amgen resolves G-CSF patent litigation With Teva
Amgen has announced that the U.S. District Court in Pennsylvania has entered final judgment and a permanent injunction against Teva Pharmaceuticals prohibiting them from infringing Amgen’s patents relating to human G-CSF (granulocyte colony-stimulating factor) and methods for its use...

Abbott confirms long-term commitment to HIV care with the planned development of new formulations
Abbott has announced that it plans to develop two new formulations of its HIV medicines, Kaletra (lopinavir/ritonavir) and Norvir (ritonavir), to offer new formulation options for people living with HIV-1...

Novartis begins shipment of Fluvirin®
Novartis has started shipping seasonal influenza vaccine to its US customers for the 2011-2012 influenza season. Early delivery of seasonal influenza vaccine will ensure healthcare professionals have the ability to provide the earliest possible protection against influenza...

Pertuzumab combined with Herceptin and chemotherapy significantly extended the time people with HER2-positive metastatic breast cancer lived without their disease getting worse
Roche has announced that CLEOPATRA, a pivotal Phase III study, met its primary endpoint...

ICON acquires Firecrest Clinical
ICON plc has announced the acquisition of Firecrest Clinical, a market-leading provider of technology solutions that boost investigator site performance and study management...

Cephalon shareholders approve acquisition by Teva
Cephalon, Inc. announced that its stockholders voted to approve the TEVA proposal to acquire Cephalon...

Events, conferences & exhibitions:

HUPO 2011
4 - 7 September 2011 Geneva, Switzerland

RNAi & miRNA Europe
8 - 9 September 2011 Munich, Germany

qPCR Europe
8 - 9 September 2011 Munich, Germany

Pharma eMarketing Congress 2011
13 - 14 September 2011 Lisbon, Portugal

MipTec 2011
20 - 22 September 2011 Basel, Switzerland

ADME, PK/TK, and Drug Metabolism in Drug Discovery and Development
20 - 22 September 2011 Dublin, Ireland

Pharma Outsourcing and Procurement Summit 2011
26 - 27 September 2011 Berlin, Germany

The Drug Development Process – From Discovery to Commercialization
28 - 30 September 2011 Dublin, Ireland

Whitepaper: The importance of being profiled - Improving drug candidate safety and efficacy using cross-target profiling

 

Profiling of putative lead compounds against a representative panel of important enzymes, receptors, ion channels and transporters is an excellent way to establish a preliminary view of potential issues that might later hamper development. An early idea of which off-target activities must be minimized can save valuable time and money during the preclinical lead optimization phase if pivotal questions are asked beyond the usual profiling at hERG. The best data for critical evaluation of activity at GPCRs and ion channels is obtained using functional assays, since binding assays cannot detect all interactions and do not provide information on whether the interaction is that of an agonist, antagonist, or allosteric modulator. This overview discusses the benefits of in vitro assays, specific decision points where profiling can be of immediate benefit, and highlights relevant profiling services offered by Merck Millipore.

Featured company

Other companies featured in our directory include:

Accugenix Inc.
- Almac
- BD Diagnostics
- bioMérieux
- BMG LABTECH GmbH
- Bruker Daltonik GmbH
- CAMO Software AS
- Cisbio Bioassays
- Colder Products Company
- Comark Instruments
- DiscoveRx Corporation
- Expo Technologies, LLC.
- Freeman Technology
- GE Analytical Instruments
- HACH LANGE GMBH
- HORIBA Scientific
- Hudson Robotics, Inc.
- IDBS
- Natoli Engineering Company, Inc.
- Peter Huber Kältemaschinenbau
- Randox Pharma Services
- Rapid Micro Biosystems
- Sapient Discovery
- Smithers Viscient
- Synbiosis
- Syngene
- TOPRA
- Waters Corporation
- Watson-Marlow Pumps Group

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