Each month, the NHS Blood and Transplant Systematic Review Initiative provides an overview of the most important new publications in transfusion medicine. All content is sourced from the Transfusion Evidence Library which is free to access worldwide.
COVID-19 publications are included in this alert.

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Transfusion thresholds for guiding red blood cell transfusion.
Carson, J.L., et al. (2021). The Cochrane Database of Systematic Reviews.
PICO Summary available

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Confirmation Bias Affects Estimation of Blood Loss and Amniotic Fluid Volume: A Randomized Simulation-Based Trial.
Atallah, F., et al. (2021). American Journal of Perinatology.

Efficacy and Safety of Intravenous Iron Therapy for Treating Anaemia in Critically ill Adults: A Rapid Systematic Review With Meta-Analysis.
Geneen, L.J., et al. (2021). Transfusion Medicine Reviews. [Record in progress]

Red blood cell transfusion in myelodysplastic syndromes: A systematic review.
Kaka, S., et al. (2021). Transfusion Medicine.

Preemptive antifibrinolysis: its role and efficacy in hip-fracture patients undergoing total hip arthroplasty.
Liu, J., et al. (2021). The Journal of Arthroplasty. [Record in progress]

Tranexamic Acid for Prevention of Hemorrhage in Elective Repeat Cesarean Delivery - A Randomized Study.
Ogunkua, O.T., et al. (2022). American Journal of Obstetrics & Gynecology.  [Record in progress]

Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia.
Peffault de Latour, R., et al. (2022). The New England Journal of Medicine.

Iron chelation therapy in patients with low- to intermediate-risk myelodysplastic syndrome: A systematic review and meta-analysis.
Yang, S., et al. (2021). British Journal of Haematology. [Record in progress]

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Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
Berger, J.S., et al. (2022). JAMA.

Randomized Controlled Trial of Early Outpatient COVID-19 Treatment with High-Titer Convalescent Plasma.
Sullivan, D.J., et al. (2021). medRxiv. [Record in progress]

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The Systematic Review Initiative (SRI) is a clinical research group established in 2001 by NHS Blood and Transplant (NHSBT) and funded by the UK Blood Services. The primary objective of the SRI is to “develop the evidence base for the practice of transfusion medicine”, by undertaking systematic reviews and other evidence-based medicine research projects in the transfusion field. @sritransfusion