No images? Click here T1D Week in Review (WiR): your go to Friday highlight reel of T1D research. Hot basic science papers, clinical papers, T1D data papers, review/op-ed papers, T1D jobs, upcoming ATEs, grant deadlines, hot ticket events, T1D business updates plus this week's watch & listen. Stay informed and current for free. We attended and reported on the nPOD 2024 scientific meeting. Check out our nPOD 2024 page to view talk summaries for each key question and oral abstract section, a summary of the "shark tank" session, and the "heard on the street" interviews. HOT Basic Science & Translational Papers fresh off the press 🐭 = mouse study //🐴 = Horse study // 🐀 = rat study Interferons are key cytokines acting on pancreatic islets in type 1 diabetesFebruary 26, 2024CD4+ T cells from individuals with type 1 diabetes respond to a novel class of deamidated peptides formed in pancreatic isletsFebruary 22, 2024Analyzing Gene Expression After Administration of Low-Intensity Therapeutic Ultrasound in Human Islet CellsFebruary 26, 2024The type 1 diabetes susceptibility locus Idd5 favours robust neonatal development of highly autoreactive regulatory T cells in the NOD mouseFebruary 9, 2024Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetesFebruary 26, 2024Beta-Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5February 28, 2024Cellular Advanced Glycation End Products Aggravate the Immune Response in Mononuclear Cells from Patients with Type 1 DiabetesFebruary 22, 2024CEBPA Overexpression Enhances β-Cell Proliferation and SurvivalFebruary 9, 2024Cell-surface ZnT8 antibody prevents and reverses autoimmune diabetes in miceFebruary 24, 2024Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreasFebruary 27, 2024Massively Parallel Reporter Assay Confirms Regulatory Potential of hQTLs and Reveals Important Variants in Lupus and Other Autoimmune DiseasesFebruary 22, 2024RFX6 Maintains Gene Expression and Function of Adult Human Islet α-CellsDecember 8, 2023HOT Clinical Papers fresh off the press A novel gain-of-function STAT3 variant in infantile-onset diabetes associated with multiorgan autoimmunityFebruary 26, 2024Nocturnal hypoglycemia is associated with next day cognitive performance in adults with type 1 diabetes: Pilot data from the GluCog studyFebruary 21, 2024Continuous Glucose Monitoring Time Below Range Predicts Impaired Epinephrine Response to Hypoglycemia in Patients With Type 1 DiabetesFebruary 23, 2024PRE1BRAZIL Protocol: A Randomized Controlled Trial to Evaluate the Effectiveness and Safety of the DPP-4 Inhibitor Alogliptin in Delaying the Progression of Stage 2 Type 1 DiabetesFebruary 21, 2024CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-upFebruary 22, 2024Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes, the HypoRESOLVE hypoglycaemic clamp studyFebruary 20, 2024T1D Data fresh off the press Predictive biomarkers of rapidly developing insulin deficiency in children with type 1 diabetesFebruary 27, 2024Advances in risk predictive performance of pre-symptomatic type 1 diabetes via the multiplex Antibody-Detection-by-Agglutination-PCR assayFebruary 8, 2024The Importance of Trial Design in Evaluating the Performance of Continuous Glucose Monitoring Systems: Details MatterFebruary 23, 2024Computational Analysis of B-Cell Receptor (BCR) Immune Repertoires with AbalignFebruary 4, 2024Glycemic variability assessed using continuous glucose monitoring in individuals without diabetes and associations with cardiometabolic risk markers: A systematic review and meta-analysisFebruary 20, 2024Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY studyFebruary 27, 2024Regulatory B Cells-Immunopathological and Prognostic Potential in HumansFebruary 18, 2024Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populationsFebruary 19, 2024Genetically predicted circulating interleukin-18 levels are associated with risk of systemic lupus erythematosus and type 1 diabetesFebruary 26, 2024New-onset autoimmune disease after COVID-19February 8, 2024HOT Reviews & Op-eds fresh off the press Omics to Unveil Diabetes Mellitus Pathogenesis and Biomarkers: Focus on Proteomics, Lipidomics, and MetabolomicsFebruary 27, 2024Interactions between the Exocrine and the Endocrine PancreasFebruary 19, 2024Genetic and Epigenetic Aspects of Type 1 Diabetes Mellitus: Modern View on the ProblemFebruary 8, 2024Advances in basic research on glucagon and alpha cellsFebruary 26, 2024Editorial: Regulation of immune cell trafficking in autoimmune diseasesFebruary 13, 2024Regulatory Issues fresh off the press Watch
Find Your Dream JobUpcoming Ask the ExpertsHot Ticket Event & OpportunitiesNIH-CZI Junior Investigators Atlas Builders MeetingThis 2-day meeting will bring together biologists, physician scientists, computational biologists, and other computational experts in the early stages of their careers from the Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network, Human Tumor Atlas Network (HTAN), The Human BioMolecular Atlas Program (HuBMAP), Kidney Precision Medicine Project (KPMP), GenitoUrinary Development Molecular Anatomy Project (GUDMAP), Cellular Senescence Network (SenNet), Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative - Cell Census Network (BICCN), Human Islet Research Network (HIRN) and Chan Zuckerberg Initiative (CZI) Seed Network to work towards building atlases of tissue organization at an unprecedented resolution for answering fundamental questions in human health and disease. Approaching Grant DeadlinesHuman Islet Research Network - Consortium on Modeling Autoimmune Diabetes (HIRN-CMAD): This Notice of Funding Opportunity (NOFO) welcomes applications for the Consortium on Modeling Autoimmune Diabetes (CMAD) that supports the development of in vitro and in vivo models of type 1 diabetes (T1D) to enable studies of human T1D pathophysiology and to serve as platforms for preclinical assessments of new T1D interventions. CMAD is part of the Human Islet Research Network (HIRN).HIRNApplication Due Date: March 20, 2024Business UpdatesvTv Therapeutics Announces $51 Million Private Placement from Healthcare-focused Institutional Investors and the JDRF T1D FundBreakthrough research unveils β-cell dynamics in Type 1 diabetesInnovative MicroGlucagon solution aims to transform insulin therapy for type 1 diabeticsTiplineSubmit papers or job listings and we will feature them on our website & the next T1D WiRWeekly SolveFollow us on twitter @thesugarscience and tweet the T1D paper this figure is from and tag us! First person to get it 3 in a row correct wins $50 Amazon Gift Card.The answer to last week: T1D Paper: Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase |