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EDITOR'S NOTE: Big4Bio newsletters will not be published from Dec 16, 2025, to Jan 4, 2026; they will resume distribution on Monday, Jan 5, 2026.

DEcember 12, 2025
Covering Life Sciences Drugs, Diagnostics, Devices, Digital Health
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Press Releases

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  • BioPorto: Changes to the Executive Management More
  • Centessa Pharmaceuticals: CEO Transition as Company Advances Strategy to Extend Orexin Leadership Into Multiple Neuroscience Indications More
  • Innoviva Specialty Therapeutics: Publication in The Lancet of Positive Zoliflodacin Phase 3 Data for the Treatment of Uncomplicated Urogenital Gonorrhea More More*
  • Insilico Medicine and TaiGen: Achieves License Agreement to Develop and Commercialize AI-driven PHD Inhibitor for Anemia of Chronic Kidney Disease (CKD) More
  • Marengo: Will Present Initial Results From Invikafusp Alfa and TRODELVY Combination Study, STARt-002, at the 2025 San Antonio Breast Cancer Symposium More
  • Pillar Biosciences and AstraZeneca: Expand Liquid Biopsy Access Partnership to China More
  • Relay Therapeutics: Efficacy Subset Analysis of Zovegalisib (RLY-2608) + Fulvestrant in Breast Cancer Patients Pre-Treated With SERD or With ESR1 Mutations at SABCS 2025 More
  • Sōlaria Biō: Breakthrough Study Demonstrating Connection Between Gut Barrier, Inflammation and Bone Health More
  • TransCode Therapeutics and Quantum Leap Healthcare Collaborative: Launch a Phase 2a Dose-expansion Trial With TTX-MC138, Following Positive Readouts From TransCode’s Phase 1 Trial More
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Financial News

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  • Dyne Therapeutics: Closing of Upsized Public Offering of Common Stock and Full Exercise by Underwriters of Option to Purchase Additional Shares More
  • Enveric Biosciences: Exercise of Warrants for $3.1 Million Gross Proceeds More
  • Get Full Access to BYTE51 Life Sciences Intelligence for 50% Off  More
  • JPM Week Conference Readiness Packages (Big4Bio Subscriber Discount) More
  • Kymera Therapeutics: Closing of Upsized $602 Million Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares More
  • Navigating Post-IPO Financial Reporting More

Media/Misc Coverage

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  • BioPharmGuy News: Pre-Holiday Roast, New Flu Dropped, Purdue Tumbles, High Energy Decision More
  • More on Rhythm Reporting Imcivree’s Key Weight Loss Data From Phase 2 Prader-Willi Trial More*
  • Pre-Clinical Trial Giant Eyes Organ-on-a-Chip Companies After Activist Investor Pressure More*
  • Predicting Trends and Aligning Priorities: How Point32Health’s New CEO Plans to Break Even More*
  • Sarepta CEO Given First Equity Award in 8 Years More*
  • Subscribe to LifeSci Startup for Updates on US Startups More
  • The Big4Bio Podcast: Every Moment Matters: Integrating AI into Drug Discovery Podcast

Companies

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Career Center

Premier Executive Search and Talent Advisory Firm Slone Partners Launches Fractional Talent Service to Deliver On-Demand Leaders and Specialists
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  • M&A in Life Sciences: The Turning Tide – Why Now is a Strategic Inflection for Biopharma and Biotech More
  • ICYMI: CEO’s Perspective: Big Moves Come with Big Responsibility More
  • ICYMI: CEO’s Perspective: The High Cost of Job Hopping More
  • ICYMI: Elevating Executive Presence: A Blueprint for Life Sciences and Biotech Leaders More
  • ICYMI: The Power of Peer Learning - Why Even Top Biotech Leaders Need Mentorship More
  • ICYMI: What’s Next in Precision Medicine: Leadership Challenges and Opportunities More
  • The Rise of Fractional Talent in Life Sciences: What to Expect in 2026 More

Event Center

Note: Events may be in any Big4Bio region or virtual
Biotech Showcase, Jan 12-14
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  • Know Before You Go: AI in 2026 — Signals, Risks, and Real-World Impact (Pre-JPM Event) Jan 6
  • BLPN Investor Summit Jan 8-10

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