Each month, the NHS Blood and Transplant Systematic Review Initiative provides an overview of the most important new publications in transfusion medicine, enhanced with PICO Summaries.

All content is sourced from the Transfusion Evidence Library which is free to access worldwide.

Click here for the web version of the Transfusion Evidence Alert.

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Association between tranexamic acid and decreased periprosthetic joint infection risk in patients undergoing total hip and knee arthroplasty: a systematic review and meta-analysis of over 2 million patients.
Elmenawi, K.A., et al. (2024). The Journal of Arthroplasty. [Record in progress].
PICO Summary available

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A review and analysis of outcomes in randomized clinical trials of plasma transfusion in patients with bleeding or for the prevention of bleeding: the BEST collaborative study.
Apelseth, T.O., et al. (2024). Transfusion. [Record in progress].

The statistical fragility of tranexamic acid use in the orthopaedic surgery literature: a systematic review of randomized controlled trials.
Brown, A.N., et al. (2024). The Journal of the American Academy of Orthopaedic Surgeons.

Blood donation for iron removal in individuals with HFE mutations: study of efficacy and safety and short review on hemochromatosis and blood donation.
Infanti, L., et al. (2024). Frontiers in Medicine.

Defining ultra-massive transfusion through a systematic review.
Meyer, C.H., et al. (2024). American Journal of Surgery.

Intravenous immunoglobulin for the treatment of severe maternal alloimmunization: individual patient data meta-analysis.
Mustafa, H.J., et al. (2024). American Journal of Obstetrics and Gynecology. [Record in progress].

Fewer severe infections with tranexamic acid in patients with hematologic malignancies.
Poston, J.N., et al. (2024). Research and Practice in Thrombosis and Haemostasis.

Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease.
Saraf, S.L., et al. (2024). Blood Advances. [Record in progress].

Tranexamic acid versus placebo in individuals with intracerebral haemorrhage treated within 2 h of symptom onset (STOP-MSU): an international, double-blind, randomised, phase 2 trial.
Yassi, N., et al. (2024). The Lancet. Neurology.

Efficacy and safety of immunosuppressive therapy combined with eltrombopag for severe aplastic anemia: a systematic review and meta-analysis.
Zhang, Y., et al. (2024). Systematic Reviews.

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The Systematic Review Initiative (SRI) is a clinical research group established in 2001 by NHS Blood and Transplant (NHSBT) and funded by the UK Blood Services. The primary objective of the SRI is to “develop the evidence base for the practice of transfusion medicine”, by undertaking systematic reviews and other evidence-based medicine research projects in the transfusion field. @sritransfusion