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T1D Week in Review (WiR): your go to Friday highlight reel of T1D research. Hot basic science papers, clinical papers, T1D data papers, review/op-ed papers, T1D jobs, upcoming ATEs, grant deadlines, hot ticket events, T1D business updates plus this week's watch & listen. Stay informed and current for free.
Made by scientists and clinicians for scientists, clinicians, and trainees.
All the signal, none of the noise
HOT Basic Science & Translational Papers
fresh off the press
Identification of unique cell type responses in pancreatic islets to stress
July 2, 2024
The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo
July 3, 2024
Identification of functional enhancer variants associated with type I diabetes in CD4+ T cells
June 14, 2024
Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans With FGFR1 Mutations
June 13, 2024
Reduced nephrin tyrosine phosphorylation enhances insulin secretion and increases glucose tolerance with age
July 2, 2024
Resolving human α versus β cell fate allocation for the generation of stem cell-derived islets
June 21, 2024
GABA-mediated inhibition of human CD4+ T cell functions is enhanced by insulin but impaired by high glucose levels
June 28, 2024
Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ
July 1, 2024
IGF-1 Peptide Mimetic-functionalized Hydrogels Enhance MSC Survival and Immunomodulatory Activity
July 2, 2024
Ca2+ signaling and metabolic stress-induced pancreatic β-cell failure
July 1, 2024
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
May 28, 2024
Interconnected lineage trajectories link conventional and natural killer (NK)-like exhausted CD8+ T cells beneficial in type 1 diabetes
June 27, 2024
TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting Wnt and BMP signaling
June 16, 2024
Proinflammatory cytokine-induced alpha-cell impairment in human islet microtissues is partially restored by dual incretin receptor agonism
June 27, 2024
Gene expression patterns and DNA methylation of neuron and pancreatic β-cell developments in zebrafish embryos treated with bisphenol F and AF
May 28, 2024
HOT Clinical Papers
fresh off the press
Islet autoantibody frequency in relatives of children with type 1 diabetes who have a type 2 diabetes diagnosis
June 27, 2024
A pilot study on the characterization and correlation of oropharyngeal and intestinal microbiota in children with type 1 diabetes mellitus
June 13, 2024
INfluenza VaccInation To mitigate typE 1 Diabetes (INVITED): a study protocol for randomised, double-blind, placebo-controlled clinical trial in children and adolescents with recent-onset type 1 diabetes
July 1, 2024
Glycemic Risk Index (GRI) in a Cohort of Patients with type 1 diabetes mellitus stratified by the coefficient of variation. A real-life study
July 1, 2024
Oral Insulin Delay of Stage 3 Type 1 Diabetes Revisited in HLA DR4-DQ8 Participants in the TrialNet Oral Insulin Prevention Trial (TN07)
July 1, 2024
A unified metric of human immune health
July 3, 2024
Blood immune cell profiling in adults with longstanding type 1 diabetes is associated with macrovascular complications
June 30, 2024
Frequency of C-peptide and antibody levels (anti GAD, Islet cell antibodies, insulin auto antibodies) in children of Pakistan with Type-1 diabetes
July 1, 2024
Effect of hyperglycemia and empagliflozin on markers of cardiorenal injury and inflammation in patients with type 1 diabetes
July 1, 2024
Type 1 diabetes prevention clinical trial simulator: Case reports of model-informed drug development tool
July 3, 2024
Closed-loop systems in Type 1 diabetes and antitumor necrosis factor alpha therapy: Are currently available algorithms prepared for sudden changes in insulin sensitivity?
June 16, 2024
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
June 27, 2024
Antibodies against glutamic acid decarboxylase in intravenous immunoglobulin preparations can affect the diagnosis of type 1 diabetes mellitus
July 2, 2024
Lessons from other Diseases
fresh off the press
Identification of common genetic factors and immune-related pathways associating more than two autoimmune disorders: implications on risk, diagnosis, and treatment
July 2, 2024
Association of autoantibody concentrations and trajectories with lupus nephritis histological features and treatment response
July 4, 2024
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis
July 1, 2024
T1D Data
fresh off the press
HOT Reviews & Op-eds
fresh off the press
The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes
July 1, 2024
Gamma-aminobutyric acid for delaying type 1 diabetes mellitus: an update
June 30, 2024
Ameliorating and refining islet organoids to illuminate treatment and pathogenesis of diabetes mellitus
June 27, 2024
Changing the location of proteins on the cell surface is a promising strategy for modulating T cell functions
July 1, 2024
Integration of Electrospun Scaffolds and Biological Polymers for Enhancing the Delivery and Efficacy of Mesenchymal Stem/Stromal Cell Therapies
June 24, 2024
Dendritic Cells for Type 1 Diabetes — Emerging Approaches for Tertiary Prevention
June 25, 2024
The Multifaceted Role of Tissue-Resident Memory T Cells
June 1, 2024
Global Trends and Frontier in Research on Pancreatic Alpha Cells: A Bibliometric Analysis from 2013 to 2023
June 1, 2024
Engineering an Insulin Complex to Treat Diabetes
June 19, 2024
A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome
July 1, 2024
The Role of Cytokines and T Cells as Mediators of Inflammatory Pathology in Type 1 Diabetes and COVID-19
June 1, 2024
Continuous glucose monitoring in neonates: challenges and opportunities
June 28, 2024
Watch
- Nick Thomas, MD PhD, University of Exeter
- Discusses: Adult onset type 1 diabetes: Insights and unanswered questions
Upcoming Ask the Experts
Grants
Danish Diabetes and Endocrine Academy Grant Opps
We offer grants to support talented early-career researchers and visiting researchers in diabetes, metabolism, and classical endocrinology. You can learn more about our grant schemes and application processes below, as well as our funding opportunity for education and networking activities.
Due: September 11, 2024
Business Updates
Most Read Paper of Last Week
Loss of insulin-expressing extra-islet cells in type 1 diabetes is accompanied with increased number of glucagon-expressing extra-islet cells
