Beta Cell Dysfunction Occurs Independently of Insulitis in T1D Pathogenesis

December 29, 2024

Crosslinked alginate-chitosan based scaffold functionalized with VEGF-A for the beta-pancreatic cells support

January 1, 2025

Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells

December 26, 2024

Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune checkpoint ligands can suppress autoimmune responses in type 1 diabetes

January 6, 2025

Transplant immunosuppressant therapies induce unique functional changes in lymph node and re-shape gut immune homeostasis

January 3, 2025

Computational Insights into the Allosteric Behavior of Mini Proinsulin Driven by C Peptide Mobility

January 8, 2025

The Inversion of Naive-to-Memory T Cell Ratios With Age: Potential Links to Autoimmunity and the Role of Lifetime Infection History

January 8, 2025

DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells

January 2, 2025

Targeted animal models for preclinical assessment of cellular and gene therapies in pancreatic and liver diseases: regulatory and practical insights

November 19, 2024

Mapping histological and functional maturation of human endocrine pancreas across early postnatal periods

December 22, 2024

UTX Epigenetically Imposes a Cytolytic Effector Program in Autoreactive Stem-like CD8+ T cell Progenitors

December 22, 2024

Delineating JunB's Crucial Function in Mature Th17 Cells through Inducible Targeted Protein Degradation

January 6, 2025

Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target

December 24, 2024

Bradykinin attenuates NiSO4-induced autophagy in MIN6 cells and protects islet function in mice by regulating the PI3K/AKT/mTOR signaling pathway

January 4, 2025

Evaluation of Pancreatic β-cell Differentiation Efficiency of Human iPSC Lines for Clinical Use.

2024

TTMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion

December 17, 2024

Hydrogel injection molded complex macroencapsulation device geometry improves long-term cell therapy viability and function in the rat omentum transplant site

January 3, 2025

ISG15 increases the apoptosis of β cells in type 1 diabetes

January 5, 2025

L-type Calcium Channel Blockade Worsens Glucose Tolerance and β-Cell Function in C57BL6/J Mice Exposed to Intermittent Hypoxia

January 6, 2025

Developmental beta-cell death orchestrates the islet's inflammatory milieu by regulating immune system crosstalk

January 6, 2025

Structural conservation and divergence across the Receptor Tyrosine Kinase superfamily

January 2, 2025

Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes

January 4, 2025

IFN-α neutralizing antibodies distinguish LADA from early-onset type 1 diabetes

January 6, 2025

BNT162b2 mRNA vaccine elicits robust virus-specific antibodies but poor cross-protective CD8+ memory T cell responses in adolescents with type 1 diabetes

January 3, 2025

Association between the onset of diabetic retinopathy and thickness changes in the retina and choroid of children with type 1 diabetes: A three-year longitudinal study

January 3, 2025

Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis

January 6, 2025

Readiness of adults with type 1 diabetes and diabetes caregivers for diabetes distress monitoring using a voice-based digital health solution

January 2, 2025

A Glucose Fraction Independent of Insulin Secretion: Implications for Type 1 Diabetes Progression in Autoantibody-Positive Cohorts

January 6, 2025

Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial

January 4, 2025

Inhibition of leukotrienes and their potential role in type 1 diabetes pathogenesis: implications for montelukast as a therapeutic agent: a case report

December 18, 2024

The Relationship of Serum Diabetes Antibodies With the Development of Early Diabetic Retinopathy Findings in Children With Type 1 Diabetes Mellitus

December 30, 2024

Paediatric-to-adult transition in type 1 diabetes: A two-centre experience of a structured program, 2014 to 2022

January 7, 2025

The overlap between type 1 diabetes and celiac disease in children and the role of tTG-IgA positivity in endoscopy decision

January 8, 2025

Predicting and Ranking Diabetic Ketoacidosis Risk among Youth with Type 1 Diabetes with a Clinic-to-Clinic Transferrable Machine Learning Model

January 6, 2025

EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents

January 2, 2025

Use of Cardioprotective Adjuncts in Type 1 Diabetes

January 6, 2025

Elevated Levels of Serum Alpha-2-Macroglobulin Associate with Diabetes Status and Incident Cardiovascular Disease in Type 1 Diabetes

January 4, 2025

Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation

January 8, 2025

Integrative proteogenomic analyses provide novel interpretations of type 1 diabetes risk loci through circulating proteins

January 6, 2025

The Virtual DCCT: Adding Continuous Glucose Monitoring to a Landmark Clinical Trial for Prediction of Microvascular Complications

January 8, 2025

Glycemia Risk Index is Associated With Risk of Albuminuria Among Individuals With Type 1 Diabetes

January 8, 2025

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies

January 3, 2025

Imprecision nutrition? Intraindividual variability of glucose responses to duplicate presented meals in adults without diabetes

January 2, 2025

Do continuous glucose monitoring (CGM) metrics predict macrovascular and microvascular complications in diabetes? The FACULTY protocol of a retrospective real-world cohort study

January 8, 2025

TLS_Finder: An algorithm for Identifying Tertiary Lymphoid Structures Using Immune Cell Spatial Coordinates

December 26, 2024

Predicting 90 Days of Intermittently Scanned Continuous Glucose Monitoring Data in Subjects With Type 1 Diabetes on Multiple Daily Injection Therapy

January 7, 2025

A case study on using a large language model to analyze continuous glucose monitoring data

January 7, 2025

The Longer, the Better: Continuous Glucose Monitoring Use for ≥90% Is Superior to 70%-89% in Achieving Tighter Glycemic Outcomes in Children

January 6, 2025

Glucokinase: from allosteric glucose sensing to disease variants

January 8, 2025

Non-invasive blood glucose monitoring using PPG signals with various deep learning models and implementation using TinyML

January 2, 2025

Large-scale multicenter study reveals anticitrullinated SR-A peptide antibody as a biomarker and exacerbator for rheumatoid arthritis

January 3,  2025

Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta

December 21,  2024

Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases

January 7, 2025

Abnormal glucagon secretion contributes to a longitudinal decline in glucose tolerance

January 3,  2025

Blood DNA virome associates with autoimmune diseases and COVID-19

January 3,  2025

Human iPSC-derived neural stem cells engraft and improve pathophysiology of MPS I mice

December 12, 2024

CAR T-cell therapy for systemic lupus erythematosus: current status and future perspectives

December 18, 2024

GLP-1R Gene Polymorphisms and Metabolic Traits During Childhood and Adolescence: The EPOCH Study

December 18,  2024

Proteomic and Metabolomic Signatures in Prediabetes Progressing to Diabetes or Reversing to Normoglycemia Within 1 Year

January 2,  2025

Aging-dependent Change in Th17 and Cytokine Response in Multiple Sclerosis

December 20, 2024

The identification of a SARs-CoV2 S2 protein derived peptide with super-antigen-like stimulatory properties on T-cells

January 6, 2025

Safety and efficacy of CAR-T cell therapy in patients with autoimmune diseases: a systematic review

January 4,  2025

Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update

January 2, 2025

Function and Regulation of Age-Associated B Cells in Diseases

January 3, 2025

Microbiota–neuroepithelial signalling across the gut–brain axis

January 2, 2025

Glucokinase: from allosteric glucose sensing to disease variants

January 2, 2025

The Age of Stem Cell Therapy

January 2, 2025

Gut microbiota mediated T cells regulation and autoimmune diseases

December 18, 2024

The impact of telemedicine on pediatric type 1 diabetes management: benefits, challenges, and future directions

December 19, 2024

Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications

January 3,  2025

Metabolic interventions as adjunctive therapies to insulin in type 1 diabetes: Current clinical landscape and perspectives

January 6, 2025

Clinical implications of human Parvovirus B19 infection on autoimmunity and autoimmune diseases

January 1, 2025

The Role of Pharmacometrics in Advancing the Therapies for Autoimmune Diseases

December 5, 2024

Draft Guidance- Accelerated Approval and Considerations for Determining Whether a Confirmatory Trial is Underway

January 6, 2025

Draft Guidance Considerations for the Use of Artificial Intelligence to Support Regulatory Decision-Making for Drug and Biological Products

January 2025

Considerations for open-label randomized clinical trials: Design, conduct, and analysis

2024

Chemically defined and growth factor-free system for highly efficient endoderm induction of human pluripotent stem cells

Effectiveness of add-on therapy with SGLT2 inhibitors or GLP-1 receptor agonists in adults with type 1 diabetes

Type 1 diabetes genetic risk score variation across ancestries using whole genome sequencing and array-based approaches