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Click here ![]() May 2, 2025 T1D Week in Review (WiR): Curating the scientific conversation in Type 1 Diabetes Basic Science & Translational Papers Multiplexed Deep Visual Proteomics Unveils Spatial Heterogeneity and Rare Endocrine States in Human Adult Pancreatic Islets4/27/25Plasmonic imaging of living pancreatic beta-cell networks4/26/25Hormone-switching islet cells: parallels to transmitter-switching neurons4/27/25Diabetes-associated MYT1 and MYT3 regulate human beta-cell insulin secretion and survival via other diabetes-risk genes4/27/25Collagen Nanofiber Reinforced Alginate Hydrogel Tube Microbioreactors for Cell Culture4/26/25Clinically compliant enrichment of human pluripotent stem cell–derived islets4/2/25Spatially organized cellular communities shape functional tissue architecture in the pancreas4/17/25NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice4/28/253D bioprinting of collagen-based high-resolution internally perfusable scaffolds for engineering fully biologic tissue systems4/23/25Comprehensive biocompatibility profiling of human pancreas-derived biomaterial4/24/25Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity4/27/25A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms4/28/25Clinical Papers Prevalence of Delayed Insulin Initiation by Age at Diagnosis in US Adults with Type 1 Diabetes4/25/25Current Status of Continuous Glucose Monitoring Use in South Korean Type 1 Diabetes Mellitus Population-Pronounced Age-Related Disparities: Nationwide Cohort Study4/28/24Numeracy skills and glycemic control in an observational, multi-centre, cross-sectional, and international study of children with T1D4/24/25Social disadvantage and technology use among adults with type 1 diabetes in Quebec4/29/25Rate of completion of blood tests after a new diagnosis of type 1 diabetes mellitus in children4/22/25DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study4/23/25Seasonal Variations in HbA1c and Body Composition: A Sex-Specific Analysis in Adolescents With Type 1 Diabetes4/28/25Innovative Educational Tools Facilitating Lifestyle and Nutritional Interventions in Type 1 Diabetes Mellitus3/14/25Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity4/30/25Musculoskeletal disorders in type 1 diabetes: Clinical phenotyping and associations with quality of life and glucose control - The French SFDT1 Cohort Study4/23/25Body-weight functional exercise promotes greater and safer blood glucose reduction compared to aerobic and strength exercises in T1D4/25/25T1D Data, -Omics, CGM, Tools Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms4/23/25Proposed minimum requirements for market approval of continuous glucose monitoring (CGM) systems4/28/25HLA haplotype diversity, islet autoantibody status and discriminative ability of type 1 diabetes genetic risk score in Indians4/25/25A Bead-Based Quantum Dot Immunoassay Integrated with Multi-Module Microfluidics Enables Real-Time Multiplexed Detection of Blood Insulin and Glucagon4/25/25Modeling the number of new cases of childhood T1D using Poisson regression and machine learning methods; a case study in Saudi Arabia4/25/25Lessons from Other Diseases Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair4/9/25Ocular immune privilege in action: the living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells3/6/25Disproportionality analysis of European safety reports on autoimmune and rheumatic diseases following COVID-19 vaccination4/27/25Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced Neurotoxicity4/26/25Neural representation of cytokines by vagal sensory neurons4/24/25GLP-1 RA and dual GIP/GLP-1 RA treatment in MODY: a descriptive case series4/22/25PD-1 activation mitigates lupus nephritis by suppressing hyperactive and heterogeneous PD-1+CD8+ T cells3/31/25Indications, efficacy, safety of rituximab in childhood-onset systemic lupus erythematosus: a retrospective study of the JIR cohort4/25/25Youth-Onset Type 2 Diabetes: What We’ve Learned From Key Youth-Onset Type 2 Diabetes Studies, What We Still Don’t Know, and Why It Is Important4/24/25A novel TIRAP-MyD88 inhibitor blocks TLR7 and TLR8-induced type I IFN responses4/28/25Optimizing pre-genetic diagnosis of monogenic diabetes: clinical thresholds for targeted testing4/23/25Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens4/25/25Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids4/30/25Vagal Splenic-Dependent Effects Influence Glucose Homeostasis, Insulin Secretion, and Histopathology of the Endocrine Pancreas in Hypothalamic Obese Male Rats4/17/25Reviews & Op-eds Decoding autoimmunity: HLA-DQβ and type 1 diabetes4/28/25Improving access to diabetes technologies in children and young people with T1D4/25/25The immune tolerance role of Bregs in inhibiting human inflammatory diseases, with a focus on diabetes mellitus4/29/25Regulation of T cell receptor (TCR) signaling by tyrosine phosphatases: Recent advances and implication for therapeutic approach in autoimmune diseases4/25/25Organoid Vascularization: Strategies and Applications4/26/25Bidirectional Communication Between the Innate and Adaptive Immune Systems4/1/25SPIRIT 2025 statement: updated guideline for protocols of randomised trials4/28/25Can the FDA fulfil its mission with a smaller workforce?4/26/25Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases4/1/25Vitamin supplementation and its effect on incident T1D and islet autoimmunity: a systematic review and meta-analysis4/9/25Business News Abbott integrates diabetes data into Epic’s electronic health recordsADOCIA to Present New Data on AdoShell® at Upcoming Scientific Conferences – Showcasing Potential Curative Treatment for Type 1 DiabetesBeta Bionics to Present at the Bank of America Securities Health Care ConferenceZucara Therapeutics Announces Second and Final Closing of US$25 Million Series B FinancingHot Ticket EventsMost Clicked Last WeekSmall things matter......Lack of extra-islet beta cells in Type 1 diabetesArtificial pancreas with engineered β cell microspheres overexpressing PD-L1 and algae ameliorate type 1 diabetesInhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantationIf you are not already... |
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