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EDITOR'S NOTE: Big4Bio newsletters will not be published from Dec 16, 2025, to Jan 4, 2026; they will resume distribution on Monday, Jan 5, 2026.

DECEMber 15, 2025
Covering Life Sciences Drugs, Diagnostics, Devices, Digital Health
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Press Releases

  • Anixa Biosciences: Transfer of IND for Breast Cancer Vaccine From Cleveland Clinic More
  • Cytokinetics: Positive CHMP Opinion of MYQORZO (Aficamten) for the Treatment of Obstructive Hypertrophic Cardiomyopathy More
  • FibroGen: Roxadustat Granted Orphan Drug Designation for the Treatment of Myelodysplastic Syndromes by the U.S. Food and Drug Administration More
  • Gilead: Investigational Single-Tablet Regimen of Bictegravir and Lenacapavir for HIV Treatment Meets Primary Endpoint in Phase 3 ARTISTRY-2 Trial More
  • Immusoft: Secures FDA Orphan Drug Designation for ISP-002 in MPS II, a Progressive Lysosomal Storage Disease More
  • Kyverna Therapeutics: Positive Topline Data From Registrational KYSA-8 Trial of Miv-cel (KYV-101) in Stiff Person Syndrome More
  • Orca Bio: Orca-T Phase 3 Data Published in Blood Demonstrate Significant Improvement in Survival Free from Chronic Graft versus Host Disease in Patients With Hematological Malignancies More
  • Profusa: U.S. Study Met Primary End Points as Presented at Late Breaking Clinical Trials at Paris Vascular Insights 2025 More
  • Quince Therapeutics: Last Patient Last Visit in Phase 3 NEAT Clinical Trial in Patients With Ataxia-Telangiectasia More
  • Spruce Biosciences: Appoints Proven Pharmaceutical Commercial Leader Keli Walbert to Board of Directors More

Financial News

Investment Banking Advisory to the Life Science Industry
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  • Chai Discovery: $130 Million Series B to Transform Molecular Discovery More More* More*
  • Dren Bio: Expands Strategic Collaboration With Sanofi to Develop Next-Generation B-Cell Depletion Therapy More More More*
  • Exclusive VC Funding Data from BYTE51, with Special Big4Bio Pricing More
  • 4DMT: New Employment Inducement Grants More
  • Jade Biosciences: $45 Million Private Placement More
  • JPM Week Conference Readiness Packages (Big4Bio Subscriber Discount) More
  • Link Cell Therapies: Launches With Vision of Advancing CAR-T Therapies in Solid and Liquid Tumors More
A single platform for private Biotech & VC intelligence. Reliable. Real-time. Affordable. BYTE51 - Exclusive pricing for Big4Bio Readers

Media/Misc Coverage

San Francisco's most flexible contract vivarium lab space: Start with a few cages and grow.
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  • More on Arcus Discontinuing Gilead-Partnered TIGIT Trials Due to Futility More More*
  • Stanford: New Center Bridges Neuroscience and Data Science to Decode the Brain More
  • Subscribe to LifeSci Startup for Updates on US Startups More 
  • The Big4Bio Podcast: Every Moment Matters: Integrating AI into Drug Discovery Podcast

Companies

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Career Center

Premier Executive Search and Talent Advisory Firm Slone Partners Launches Fractional Talent Service to Deliver On-Demand Leaders and Specialists
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  • M&A in Life Sciences: The Turning Tide – Why Now is a Strategic Inflection for Biopharma and Biotech More
  • ICYMI: CEO’s Perspective: Big Moves Come with Big Responsibility More
  • ICYMI: CEO’s Perspective: The High Cost of Job Hopping More
  • ICYMI: Elevating Executive Presence: A Blueprint for Life Sciences and Biotech Leaders More
  • ICYMI: The Power of Peer Learning - Why Even Top Biotech Leaders Need Mentorship More
  • ICYMI: What’s Next in Precision Medicine: Leadership Challenges and Opportunities More
  • The Rise of Fractional Talent in Life Sciences: What to Expect in 2026 More

Event Center

Note: Events may be in any Big4Bio region or virtual
Biotech Showcase, Jan 12-14
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  • Know Before You Go: AI in 2026 — Signals, Risks, and Real-World Impact (Pre-JPM Event) Jan 6
  • BLPN Investor Summit Jan 8-10

SEE FULL EVENT SCHEDULE AT THE BIOCALENDAR

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