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Domainex - Enrich your medicines pipeline
 

Domainex newsletter

All the latest news and industry insights from the Domainex team

 
 
 
Hayley's headshot

Hayley French, CEO

A Message from Hayley French, CEO of Domainex

As we reflect on the past year and look ahead, I am pleased to share this latest Domainex newsletter. I continue to be impressed by the strength of our science and the way our teams collaborate to solve complex discovery challenges. Our strategy remains focused on combining deep expertise with innovative technologies to deliver high-quality, integrated solutions for our partners and to support the continued growth of the business. Creating opportunities to share knowledge, challenge ideas, and connect across disciplines is central to that approach. 

This spirit was clearly reflected in our recent Science Uncorked event, which brought together Domainex scientists and the wider community to showcase the breadth of our capabilities and the progress we are making. I hope you enjoy reading more about the discussions and insights that emerged from the day.

Science Uncorked 2025

Science Uncorked, held on 27th November at Unity Campus in Cambridge, brought together Domainex scientists and the wider life-science community to share insights into early drug discovery. Through short talks, panel discussions, and poster presentations, the event highlighted how automation, AI, chemistry, and biophysics are being combined to tackle challenging targets and accelerate Lead Discovery. Key themes included direct-to-biology workflows, advances in membrane protein research, covalent screening, and emerging modalities such as molecular glues and RNA-targeted small molecules. The afternoon also offered a relaxed opportunity to connect with the Domainex team over drinks and conversation. Overall, Science Uncorked showcased the collaborative spirit and innovation behind Domainex’s approach to modern drug discovery.

Read more about the event
 
Covalent Drug Discovery
 

Domainex and Pharmacelera Join Forces to Accelerate Discovery of Molecules Targeting Transmembrane Proteins

In August we announced a strategic collaboration with Pharmacelera, a pioneer in AI-based molecular modelling technologies, focused on transmembrane proteins implicated in a broad range of diseases.

 
Poppy Wood presenting at Drug Discovery 2025
 

Domainex attends Drug Discovery 2025 Liverpool, hosted by ELRIG

October 2025 saw Domainex attend Drug Discovery 2025 Liverpool, hosted by ELRIG, the leading drug discovery conference throughout Europe.

 
Domainex Team at Trek to Remember
 

Trek to Remember

On the 2nd August 2025, a group of walkers from Domainex trekked across the Suffolk coast as part of the ‘Trek to Remember’ event organised by Alzheimer’s UK. Our team raised over £4,000 for Alzheimer’s Society UK!

New publications

Synthesis in Review: Expanding Chemical Space with Skeletal Editing and C–H Activation

Synthesis in Review: Photochemical Skeletal Editing - Atom Swapping and Carbon Deletion in Indoles, Benzofurans, and Azaarenes

Medicinal Chemistry in Review: The Discovery of Elironrasib (RMC-6291)

New Predictive Tools for CADD: SMID, 3DPSA, and pKBHX for Smarter Drug Design

 

 

 

 

Upcoming events

Drug Discovery Chemistry 2026
13-16 April 2026 | San Diego, US

37th BMCS Spring Symposium on Medicinal Chemistry
23 April 2026 | Hatfield, UK

Swiss Biotech Day
4-5 May 2026 | Basel, Switzerland

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Chesterford Research Park
Little Chesterford
Saffron Walden, Essex
CB10 1XL, UK
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