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Domainex newsletter

All the latest news and industry insights from the Domainex team

 
 
 
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Hayley French, CEO

A Message from Hayley French, New CEO of Domainex

I’m Hayley French and I’m delighted to introduce myself as the new Chief Executive Officer of Domainex. I have over two decades of experience in the life sciences sector working in senior commercial roles and as an attorney in pharmaceutical and biotechnology organisations. I look forward to applying my experience in strategic development, business operations, and commercialisation to continue building strong partnerships across the industry and lead Domainex through its next stage of growth.

Domainex has a strong reputation for innovation and delivery in drug discovery and I am excited to join such a talented team. We will continue to work closely with our partners and clients to build on that foundation and drive growth and success. If we've not yet met, I look forward to seeing you over the coming months.

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Covalent Drug Discovery
 

Covalent Drug Discovery: Challenges, Advances and Success Stories

Check out Dr Andrew Ratcliffe and Dr Scott Martin's recent article in International Pharmaceutical Industry on the rise and challenges of covalent drug discovery

 
Advancements in Hit Identification for Membrane Protein Drug Discovery
 

Advancements in Hit Identification for Membrane Protein Drug Discovery

In this article for Drug Target Review, Philip Rawlins explores how fragment-based screening and innovative technologies like PoLiPa (polymer nanodiscs) are helping to overcome hurdles in membrane protein drug discovery, with a focus on the Adenosine A2a receptor.

 
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Domainex Supports Sitryx's MTHFD2 Programme

Domainex is delighted to have supported Sitryx’s MTHFD2 programme which resulted in SIT047, a novel, oral inhibitor, progressing to clinical development for psoriatic arthritis. Over the course of the programme, Domainex provided an integrated team including assay biology, medicinal chemistry, structural biology and bioanalytical services.

 
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Nomination for NRG5051

We are delighted that NRG Therapeutics has achieved a key milestone with the nomination of its first development candidate, NRG5051, and has secured a $5 million award from The Michael J. Fox Foundation for Parkinson’s Research (MJFF). Domainex is proud to have supported this project by providing integrated lead optimization services including assay biology and medicinal and computational chemistry.

 
Nadine Myers and Michael Carter
 

New recruits

Welcome to the Domainex team to Nadine Myers and Michael Carter. Visit our website to view the current available opportunities and find out more about working at Domainex.

New publications

Medicinal Chemistry in Review: ‘Direct-to-biology’ drives optimisation of a cell-active covalent inhibitor of WRN helicase

Synthesis in Review: Synthesis, Characterisation, and Assessment of Angular Spirocyclic Azetidines in Drug Discovery and Light-Induced Aromatic Denitrative Chlorination

Medicinal Chemistry in Review: AstraZeneca report on the development of actively transported Arginase inhibitor prodrugs to achieve oral bioavailability

D2B or Not D2B?: An Introductory Guide to Direct-to-Biology

Synthesis in Review: An Air-Stable Iridium Precatalyst for C-H Borylation and a Photochemical Strategy for Azole Permutations

Medicinal Chemistry in Review: Orthogonally Reactive Linkers and a D2B Approach: Discovery of a CNS Active GSK3 Degrader

Medicinal Chemistry in Review: A Team at Pfizer Report the Discovery of Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy

Featured Services

Project Management and Consultancy

Biotherapeutics

Covalent Inhibitors

Molecular Glues

Ternary Complex Formation

 

Upcoming events

On Helix
3 July 2025 | Cambridge, UK

28th International symposium: Synthesis in organic chemistry
21-24 July 2025 | Cambridge, UK

Postgraduate Symposium XVII – Biological and Medicinal Chemistry Symposium for Postgraduates 2023
14-17 September 2025 | Oxford, UK

Fragment Based Lead Discovery
21-24 September 2025 | Cambridge, UK

Discovery on Target 2025
22-25 September 2025 | Boston, US

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Domainex is a registered company (number 4336899)
Chesterford Research Park
Little Chesterford
Saffron Walden, Essex
CB10 1XL, UK
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