Weekly Bulletin

Season’s Greetings from the Infectious Diseases Clinical Research Consortium

We want to express our sincere gratitude for all your efforts during this unprecedented year. Best wishes to you and your family for a joyous and safe holiday season and a happy and healthy new year.

 

Profile: IDCRC Site

Alabama Vaccine Research Clinic

The Alabama Vaccine Research Clinic conducts clinical trials of candidate vaccines at the University of Alabama at Birmingham (UAB). The clinic served as an Infectious Diseases Clinical Research Consortium (IDCRC) site for all of the Adaptive COVID-19 Treatment Trials (ACTT) through UAB’s role in the IDCRC Leadership Group. 

"It is great being involved in making a difference in the COVID pandemic. We have helped to develop two drugs so far! The ability to rapidly respond to the pandemic because of the existing infrastructure is one of the best strengths of the IDCRC."

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In The News

NIH: "Baricitinib plus remdesivir shows promise for treating COVID-19"

Published December 11, 2020

The combination of baricitinib, an anti-inflammatory drug, and remdesivir, an antiviral, reduced time to recovery for people hospitalized with COVID-19, according to clinical trial results published in the New England Journal of Medicine. The study was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

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Emory Health Sciences Research Blog: "Baricitinib effectively reduces COVID-19 lung inflammation in NHP model"

Published December 10, 2020

In the race to halt the COVID-19 pandemic, researchers at Yerkes National Primate Research Center of Emory University share two important findings from their latest peer-reviewed, published study in Cell.

Rhesus monkeys are a valid animal model for COVID-19 studies because the way they experience and respond to the virus has comparable similarities to the way the virus affects humans, the researchers say. And baricitinib, an anti-inflammatory medication that is FDA-approved for rheumatoid arthritis, is remarkably effective in reducing the lung inflammation COVID-19 causes when the medication is started early after infection.

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Stanwood Camano News: "Seattle Children's Hospital leads research of COVID in children"

Published December 8, 2020

At Seattle Children’s Research Institute, healthcare experts and scientists collaborate in areas like epidemiology, diagnostics, immunology, infectious disease, vaccine development and mental health, making major breakthroughs in cancer, cystic fibrosis, infectious disease, and autoimmune disorders.

The Coler Lab at Seattle Children’s Research Institute supported the Phase 1 clinical trial of an experimental coronavirus vaccine in collaboration with Kaiser Permanente Washington Health Research Institute in Seattle, part of NIAID’s Infectious Diseases Clinical Research Consortium.

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Publications

View recent journal articles featuring IDCRC-supported work below:

  • Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
  • Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination
  • Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
 

Communication Survey and Resources

Deadline: December 31, 2020

Please take a moment and complete the inaugural Infectious Diseases Clinical Research Consortium (IDCRC) communication survey. The survey will measure the success of the following year one communication goals:

  • To establish a bi-directional communication funnel
  • To establish an IDCRC brand
  • To establish internal communication channels as outlined in the GY1 strategic communication plan

The survey is anonymous and takes approximately two minutes to complete. The results will impact IDCRC communication planning for GY2 and beyond. 

Thank you for your time and invaluable feedback. Please contact epthomp@emory.edu with any questions.

COMPLETE SURVEY
 

Access IDCRC communications resources on Box or visit the web-based toolkit.

COMMUNICATION TOOLKIT
 

IDCRC-CoVPN Studies

Active Studies
Recruiting Volunteers

  • Adaptive COVID-19 Treatment Trial 4 (ACTT-4)
     

  • The ENSEMBLE Study with Janssen’s Ad26.COV2.S Investigational Vaccine
     

  • AstraZeneca Study of AZD1222
     

  • Regeneron’s 10933 and 10987 Monoclonal Antibodies, the REGN-COV2 Study
     

  • Eli Lilly’s LY3819253 Antibody, the BLAZE-2 Study

Fully Enrolled Studies
in Follow-up

  • Moderna’s mRNA-1273 vaccine, The COVE Study™

IDCRC ACTIVE AND COMPLETED STUDIES
 

Event

Virtual IDCRC Annual Meeting
January 19, 2021 | 10 a.m. - 4 p.m.

 

IDCRC Concept Quick Stats

ICP Status

  • Approved: 16
  • Administratively Not Supported: 16
  • Revise and Resubmit: 6
  • Withdrawn: 6
  • EWG Liaisons: 2
  • EWG Liaisons/DMID: 1
  • Full EWG Review: 1
  • EWG Co-Chairs: 1
  • Not Approved: 21
  • Resubmitted to ACTIV per DMID: 1
  • EMT Review: 1

EWG Assignment

  • STI: 2
  • Respiratory: 7
  • Malaria/Tropical Diseases: 2
  • COVID: 58
  • Enteric and Sexually Transmitted Infections Branch: 2
  • Parasitology and International Programs Branch: 2
  • Emerging Infections: 1

ECP Status

  • Transitioned to IDCRC for Protocol Implementation: 4
  • In Protocol Development: 2
  • On Hold: 1
  • Submitted to ACTIVE Mab Program per DMID: 1
  • Transitioned to Pediatric Working Group: 1
  • Transition to Phase III Vaccine Protocol Development: 1
  • Merged into AIRS Protocol: 2
  • Under discussion with DMID/NIAID: 1
  • Protocol Transitioned to ACTT 2: 1
  • Funded by NIAID via OBRRTR: 1
  • Approved for Protocol Development: 2
  • Another Funding Stream: 1
  • EWG Liaisons: 1
  • EMT Review, Approved for Protocol Development: 1
  • EWG Review: 1
IDCRC STUDIES
 

Please submit IDCRC news to epthomp@emory.edu for inclusion in the monthly newsletter and IDCRC.org.

VISIT IDCRC WEBSITE
 
Woodruff Health Sciences Center
Emory University
1440 Clifton Road NE
Atlanta, GA 30322, United States
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