Division of Research-On the Cutting Edge Newsletter
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December 17, 2021
In Case You Missed It:
- COVID-19: Information for NIH Applicants and Recipients of NIH Funding
- MCW is adopting the Florence eBinders™ tool with launch scheduled for September. Florence eBinders™ is a secure, FDA Part 11 and HIPAA-compliant system that replaces paper forms and physical binders, giving clinical research teams an efficient, compliant way to electronically sign, manage, store, and collaborate on study documents and to facilitate remote monitoring. | More Information
- The MCW Corporate Policy on Financial Conflicts of Interest in Research, RS.GN.020, was recently revised to incorporate oversight for industry-sponsored research, effective Aug. 15, 2021. Users listed as a Covered Person in eBridge on active PHS federal or federal pass-through proposals and awards must retake FCOI-R training and update any SFI disclosures. This training must be completed no later than Dec. 31, 2021. Review instructions to renew your training in eBridge. For inquiries, contact Research Compliance.
- CTSI Methods in Grant Preparation: This series addresses how to succinctly state overall and specific hypotheses and specific aims with affirmation and relevance; recommended for faculty, staff, and other individuals who are currently or will be working on one or more grant proposals. Wednesdays January 6 - March 31 | More Information
- Keep Greater Milwaukee Beautiful Supply Drive: 137 pairs of shoes, 56 ink cartridges, and 13 cell phones were collected during this year’s holiday drive that will be donated to KGMB to support their programming for environmental science education classes that are offered to adults and children in the community. Thank you to all who contributed!
- Abstract Deadlines and Meeting List: List will be updated each month. | More Information
Surgery Research Conference Recap, December 8
Maternal Stress and Resilience in Prenatal Diagnosis of Fetal Anomalies
Terri deRoon Cassini, MS, PhD
Associate Professor
Division of Trauma and Acute Care Surgery
Surgery Research Conference is getting revamped!
A new series will be announced soon. Thank you to our past presenters and all who have attended Surgery Research Conference!
SurPASS Tip of the Month
Cost Sharing
The policy of MCW is to include Cost Sharing only when required by the sponsor (mandatory cost sharing). Only the minimum amount of faculty effort (5% or less per faculty member) should be offered.
Cost Sharing occurs when personnel effort is not paid by the sponsor (NIH, foundation, internal MCW, etc.) but paid instead using resources within the department. For example, a PI proposing to cost share 3% effort during the year for a grant cannot use that 3% for other research, teaching, patient care, administrative activities, or other institutional commitments. Total effort cannot be more or less than 100% and is not based on a 40-hour workweek.
The MCW Cost Sharing Commitment Form documents the departmental commitment to provide Cost Sharing, describes the nature of the Cost Sharing and identifies the department source of funding for the cost shared expenditures. To ensure there is a plan for the cost share commitments, the Department of Surgery is now requiring Cost Sharing forms to be completed at time of grant application. The forms need to be filled out and signed by all parties before grant application submission to the Grants and Contracts Office via eBridge.
Procedure for completing Cost Sharing forms:
Discuss the grant and effort proposed with your Division Chief and Division Administrator.
Contact Lynn Cummings, Grants Operations Coordinator, to help with routing and completion of form. If you are submitting the application on your own, use this link to find the most current form to complete. Faculty members must sign the form and obtain the signature of Jon Mayer, Department Administrator (listed as Authorized Department Representative on form).
Upload completed form(s) to the Budget in eBridge or if not using eBridge, keep form(s) if grant is awarded.
If multiple departments are involved, the Department of Surgery is ultimately responsible for meeting all cost share commitments.
Finally, upon award, the Cost Sharing form is provided as an attachment to the semi-annual Personnel Activity Reports to remind faculty of their commitment to provide additional, contributed effort to a project.
Reference: MCW Policy BF.SP.010
Clinical Research Tip of the Month
Center for Imaging Research
Our Mission: The mission of the Center for Imaging Research (CIR) is to unite basic and clinical scientists of various disciplines to further the development and application of imaging in health and disease. Investigators from institutions across the Midwest utilize the resources available within the MCW CIR. Our state of the art facilities and technical support infrastructure provide users with tools required to perform basic and clinical imaging research studies. Investigative projects at the CIR span a wide variety of disease states and topics of technological development.
Services Offered: The CIR maintains 3 research-dedicated MRI systems, including a 3.0T GE Healthcare Discovery MR750 located in the Froedtert Pavilion, the newest generation 3.0T GE Healthcare Signa Premier located in the MRI annex to the MACC Fund Building, and a pre-clinical 9.4T Bruker Biospec located in the MRI annex.
The CIR is structured to enable the use of MRI in a broad range of research studies. Support is available from staff and faculty level physicists on a fee-for-service model. This support can be used to protocol experiments, develop novel image acquisitions, and assist in image analysis. For pre-clinical work, an animal “drop-off” service is available to aid in the preparation and handling of small animals in imaging studies. With these services, the goal of the CIR is to lower the “barrier to entry” for imaging studies. Ultimately, researchers with questions that can be answered with MRI can use the services of the CIR to tailor an imaging experiment and understand its outcome.
The CIR has an imaging study pilot award funding opportunity. Renewable $5,000 awards are available, and are reviewed and awarded on a rolling basis. Funds from these awards are available for study setup, general physics support, data analysis, and imaging expenses. For application details, please see the CIR webpage.
The following imaging equipment is dedicated for research use and is available to all funded researchers associated with the MCW CIR:
- GE Healthcare Advantage Workstation with VolumeShare 7.0
- GE Healthcare Discovery MR750 3T MRI
- GE Healthcare Signa Premier 3T MRI
- Bruker 20cm 9.4T pre-Clinical MRI
GRANT$ Alert
The Elsa U. Pardee Foundation Grant
1 year/No limit on funding
Proposal due in eBridge: December 23, 2021
Application due: December 31, 2021
The Elsa U. Pardee Foundation funds projects for a one year period which will allow establishment of capabilities of new cancer researchers, or new cancer approaches by established cancer researchers. It is anticipated that this early stage funding by the Foundation may lead to subsequent and expanded support using government agency funding. Project relevance to cancer detection, treatment, or cure should be clearly identified. By design, there are no limits set on the grant amount that can be requested. It must be reasonably and clearly supported by the scope of the project outlined in the application.
ASCO Young investigator Award (YIA)
$50,000/1 year
Proposal due in eBridge: January 3, 2022
Application due: January 10, 2022
Must be within 10 years of obtaining medical degree at time of submission, be planning an investigative career in clinical oncology, and have a mentor in the proposed research field from the sponsoring institution. Commit 60% effort in total research (not just proposed project).
2022 CTSI Pilot/Integrated Clinical and Research Ensembles (ICRE) Award
$50,000/1 year
Letter of Intent due: January 12, 2022
Proposal due in eBridge: February 22, 2022
Application due: March 1, 2022
Proposal must be inter-institutional, from 2 different CTSI partner institutions. Minimum of %5 effort for primary contact PI. Will support small, short-term feasibility studies addressing unmet clinical needs.
American Heart Association (AHA) Established Investigator Award
$80,000/5 years (10% indirect allowed)
Letter of Intent due: January 13, 2022
Proposal due in eBridge: March 16, 2022
Application due: March 23, 2022
Must be associate professor, history of substantial extramural funding. Candidate's career is expected to be in a rapid growth phase.
American Heart Association (AHA) Transformational Project Award
$100,000/3 years
Proposal due in eBridge: February 9, 2022
Application due: February 16, 2022
Successful applications are those building on strong preliminary data supportive of the hypothesis.
CESERT Pyramid Grant
Giant Robotic: $25,000, Platinum: $10,000, Diamond: $25,000, Gold: $500
Application due: February 15, 2022
Education Research Grants from the Association for Surgical Education Foundation (ASEF). Gold is for small projects within 1 year. Diamond is for mixed methods projects within 1-2 years. Platinum is for multi-institutional projects for at least 2 years. Giant Robotic is for research questions including curriculum design, training programs, assessment metrics, and patient outcomes for at least 2 years.
Herma Heart Institute Seed Money
$10,000 one-time request
Proposal due in eBridge: N/A
Application due: Reviewed quarterly
Must have an HHI faculty member as the PI or co-PI.
Abstracts Alert
Central Surgical Association (CSA) 2022 Annual Meeting
June 2-4, 2022, Milwaukee, WI
Abstract Deadline: January 6, 2022
The abstract body (not counting abstract title or author string) must be at least 50 words and not exceed 350 words. Each graph, photo, and table counts as 25 words.
Statistical evaluation of data is preferred and will result in a higher rate of acceptance.
You do not need to be a member of CSA to submit an abstract for consideration. However, if none of the authors is a member, you will need a member to sponsor your submission.
Abstracts submitted as an “Oral” Presentation Type must agree to submit a manuscript to Surgery if accepted as an Oral presentation.
Association of VA Surgeons (AVAS) 2022 Annual Meeting
April 24-26, 2022, Pittsburgh, PA
Abstract Deadline: January 7, 2022
Abstracts will be a maximum of 300 words; edit carefully and check for errors; all submitted abstracts should adhere to the following format: Introduction, Methods, Results, Conclusions; abstracts will be accepted in electronic format only
American Heart Association (AHA) Vascular Discovery 2022
May 12-14, 2022, Seattle, WA
Abstract Deadline: January 11, 2022
Categories: Aortic Aneurysm Disease; Apolipoproteins and Lipid Metabolism; Blood Coagulation, Platelet Function and Antithrombotic Therapy; Cardiovascular Precision Medicine; COVID-19; Functional Genomics and Epigenetics in Vascular Disease; Immune Mechanisms of Atherosclerosis; Immunity and Inflammation in Vascular Biology; Metabolic Disorders and Atherosclerosis; Molecular and Cellular Mechanisms of Atherosclerosis; Molecular, Developmental and Cellular Biology of Vessel Wall; Peripheral Artery Disease, Carotid Artery Disease and Stroke; Population Science and Genetics in Vascular Discovery; Sex Differences in Cardiovascular Disease; Therapeutic Targets in Atherosclerosis; Venous Thromboembolism and Lymphatic Disease
The Society for Vascular Surgery (SVS) 2022 Vascular Annual Meeting
June 15-18, 2022, Boston, MA
Abstract Deadline: January 12, 2022
The Objectives/Methods/Results/Conclusions sections are limited to 400 words total; authors are not restricted by the number of abstracts and/or videos submitted. However, no more than 12 authors per submission are allowed. Ensure ALL authors are included at the time of submission; abstract submissions must be entered in the English language; updates and edits to submissions can be made as needed prior to the submission deadline; the work represented in the abstract must NOT have been presented, published, or submitted to any other major meeting or journal prior to that year’s Vascular Annual Meeting except for: Local/regional meetings, Vascular Research Initiatives Conference; titles may not include author, institutional and/or proprietary names; papers may be presented by a student, resident or fellow; however, the senior author must be present in the audience during the discussion phase of the paper.
Endocrine Society ENDO 2022 Annual Conference
June 11-14, 2022, Atlanta, GA
Abstract Deadline: January 17, 2022
Abstracts are text-only (with a 450-word limit, including punctuation, but excluding spaces); graphics (e.g., figures and tables) are not accepted in the body of your abstract; including references is optional. If references are included, they should be included in your abstract text and will count toward the 450-word limit; to preserve the peer review process, do not include any identifying information (e.g., institution or author names) in the body of your abstract (Step 2). All co-authors/primary investigators, their institutional affiliations, and any disclosures must be entered on the Authors page (Step 3).
American Society of Clinical Oncology (ASCO) 2022 Annual Meeting
June 3-7, 2022, Chicago, IL and Virtual
Abstract Deadline: February 15, 2022
All types of oncology-related research are eligible for submission. Please note: case reports are not accepted; abstract should address scientific questions, detail clinical observations, or contain primary scientific data; data from the long-term follow-up of previously presented clinical trials may be submitted only if significant new information can be shown; Interim analysis of a prospective randomized clinical trial will be considered if it is performed as planned in the original protocol and is statistically valid; abstracts of clinically-related subjects should be combined into a single abstract. Submission of multiple abstracts on a single study may result in the rejection of one or more abstracts.
Department of Surgery Recent Publications
Precision medicine in trauma: a transformational frontier in patient care, education, and research. [Review] European Journal of Trauma & Emergency Surgery. (Davis CS, Wilkinson KH, Lin E, Carpenter NJ, Georgeades C, Lomberk G, Urrutia R)
Quality of Care for Gallstone Pancreatitis-the Impact of the Acute Care Surgery Model and Hospital-Level Operative Resources. Journal of Gastrointestinal Surgery. (Murphy PB, Oslock WM, Ingraham AM, Ricci KB, Heh VK, Santry HP)
EpiPanGI Dx: A Cell-free DNA Methylation Fingerprint for the Early Detection of Gastrointestinal Cancers. Clinical Cancer Research. (Kandimalla R, Xu J, Link A, Matsuyama T, Yamamura K, Parker MI, Uetake H, Balaguer F, Borazanci E, Tsai S, Evans D, Meltzer SJ, Baba H, Brand R, Von Hoff D, Li W, Goel A)
Long-term Outcomes of Firearm Injury Survivors in the United States: The National Trauma Research Action Plan Scoping Review. Annals of Surgery. (Orlas CP, Thomas A, Herrera-Escobar JP, Price MA, Haider AH, Bulger EM, National Trauma Research Action Plan (NTRAP) Investigators Group)
Adrenalectomy for Secondary Malignancy: Patients, Outcomes, and Indications. Annals of Surgery. (Wachtel H, Roses RE, Kuo LE, Lindeman BM, Nehs MA, Tavakkoli A, Parangi S, Hodin RA, Fraker DL, James BC, Carr AA, Wang TS, Solorzano CC, Lubitz CC)
Pneumonectomy for Pediatric Tumors-a Pediatric Surgical Oncology Research Collaborative Study. Annals of Surgery. (Polites SF, Heaton TE, LaQuaglia MP, Kim ES, Barry WE, Goodhue CJ, Murphy AJ, Davidoff AM, Langham MR, Meyers RL, Short SS, Lautz TB, Glick RD, Vasudevan SA, Bence CM, Lal DR, Baertschiger RM, Emr B, Malek MM, Dasgupta R)
Controversies in Vascular Surgery. [Review] Surgical Clinics of North America. (Brown KR, Alizadegan S)
Disparities in rectal cancer care: A call to action for all. American Journal of Surgery. (Calata J, Peterson CY)
Right ventricle pressure-volume loops for monitoring right ventricular function in left ventricular assist device patient. Artificial Organs. (Carlson SF, Smith NJ, Brown C, Joyce LD, Joyce DL)
Long-term outcome of absorbable synthetic mesh in clean ventral hernia repairs. Surgical Endoscopy. (Yu JF, Goldblatt HE, Alter-Troilo K, Hetzel E, Goldblatt MI)
SAGES Advanced GI/MIS Certificate Program. Surgical Endoscopy. (Weis JJ, Gee D, Honigsberg E, Goldblatt M, Pryor A, Scott DJ)
Anatomic location and mechanism of hiatal hernia recurrence: a video-based assessment. Surgical Endoscopy. (Linnaus ME, Garren A, Gould JC)
Underdiagnosis of primary hyperparathyroidism in patients with osteoarthritis undergoing arthroplasty. Surgery. (Park SY, Scotting O, Yen TWF, Evans DB, Wang TS, Dream S)
Thoracoscopic versus open lobectomy in infants with congenital lung malformations: A multi-institutional propensity score analysis. Journal of Pediatric Surgery. (Weller JH, Peter SDS, Fallat ME, Saito JM, Burns CR, Deans KJ, Fraser JD, Gadepalli SK, Helmrath MA, Hirschl RB, Kabre R, Lal DR, Landman MP, Leys CM, Mak GZ, Minneci PC, Wright TN, Kunisaki SM, Midwest Pediatric Surgery Consortium)
Defining the role of advanced care practitioners in pediatric surgery practice. Journal of Pediatric Surgery. (Rich BS, Fishbein J, Ricca RL, Moriarty KP, Short J, Trudeau MO, Kim SS, Rollins M, Van Arendonk KJ, Gadepalli SK, Raval MV, Dasgupta R, Rothstein DH, Glick RD, American Academy of Pediatrics Section on Surgery Delivery of Surgical Care Committee)
Disparities in utilization of outpatient surgical care among children. Surgery. (Powers RJ, Mokdad AA, Pezzin LE, Nattinger AB, Oldham KT, Van Arendonk KJ)
Saddle block anesthetic technique for benign outpatient anorectal surgery. Surgery. (Peterson KJ, Dyrud P, Johnson C, Blank JJ, Eastwood DC, Butterfield GE, Stekiel TA, Peterson CY, Ludwig KA, Ridolfi TJ)
Central Surgical Association 2020 Presidential Address: Looking within: The power and beauty of introversion. Surgery. (Yen TWF)
Superficial femoral artery stent extrusion. Journal of Vascular Surgery Cases & Innovative Techniques. (Voruganti N, Olowofela A, Wood JC, Mansukhani NA, Lewis BD, Brown KR)
Collateral Victim or Rescue Worker?-The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer. [Review] Frontiers in Cell & Developmental Biology. (He L, Lomberk G)
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