On The Cutting Edge | May 2024

May 24, 2024

Clinical Trials Day - May 20th

May 20th was Clinical Trials Day. We want to express our gratitude to all clinical research professionals, including the outstanding individuals in the Department of Surgery whose dedication and hard work are advancing medicine and developing new treatment to help patients around the world!

In Case You Missed It

Faculty Mentorship/Student Help: The Division of Research is implementing initiatives to organize the process of matching research residents and medical students with faculty members for research opportunities. These opportunities are to be strictly for volunteer work done by the student. Specifics on task work is completely up to the faculty member’s discretion. If you are interested in mentoring, please fill out this Qualtrics survey.
NIH Scientific Data Sharing Website: Whether you are involved in an NIH-funded project and want to understand which sharing policies apply to your research and how to comply, or you are a researcher looking to access scientific data from NIH-affiliated repositories, this site is for you. | More information
Department of Surgery Intranet Site: Funding Opportunities, Cultural Complications/Grand Rounds/Quality Minute presentations, Surgery Sparks of Gratitude, Global Surgical Programs, Finance/Reimbursement links, DOS Phone list, and resources for logos/fonts/templates. | More Information
Abstract Deadlines and Meeting List: List will be updated each week.| More Information

Upcoming Events

Clinical Research Coordinator Enrichment Series: Using Epic for Day-to-Day Conduct of Clinical Research | June 27, 2024, 12-1 pm. Attendees will learn how to use Epic to identify and recruit patients for research studies and link patients to studies once enrolled. Additionally, this session will cover entering study protocol orders (e.g., imaging), how to record, result and review protocol specific labs and other procedures, and communication between clinical providers and the research team.

NOTE: Room change for June!

SurPASS Tip of the Month

What Happens If a Due Date Falls on a Weekend?

With summer approaching fast and many holidays coming up, we are discussing due dates and weekends!

For applications at the NIH, the application deadline is automatically extended to the next business day. For example, the May 25, 2024 standard due date for some of our programs falls on a Saturday, which means it slides to Tuesday, May 28, 2024 (since Monday, May 27 is a Federal holiday).

For all other applications, refer to the Request for Application (RFA) or contact the sponsor for more information.

Clinical Research Tip of the Month

Early-Stage Research Regulatory Oversight Program

The primary mission of the Early-Stage Research Regulatory Oversight Program at the Medical College of Wisconsin is to collaborate with, and to aid those investigators interested in early-phase research conducted in compliance with all applicable regulations. The Program provides regulatory expertise to support the early-stage development of investigator initiated clinical research at MCW.

The purpose of the Research Oversight Program is to:

Provide education to faculty and staff who hold, or aspire to hold, Food & Drug Administration (FDA) granted Investigational New Drug (IND) and Investigational Device Exemption (IDE).
Register and track investigator held IND and IDE.
Create institutional policies to ensure FDA-regulated research complies with federal regulations.
Serve as liaison to the FDA and the Office of Human Research Protections (OHRP) for research teams and the institution.

Kristin Busse, PharmD, BCPS
Research Oversight Program Director
Assistant Professor of Pharmacy Administration and Regulatory Sciences
kbusse@mcw.edu | (414) 955-8808

GRANT$ Alert

AHRQ R01
$400,000 total costs each year for up to 5 years
GCO deadline: May 29, 2024
Application due: June 5, 2024

Health Services Research Projects

PCORI Funding Opportunities
LOI due: June 4, 2024
Application due: September 4, 2024

Multiple funding opportunities available. See link.

Agency for Healthcare Research and Quality (AHRQ) R03
$100,000 total costs for up to 2 years
GCO deadline: June 9, 2024
Application due: June 16, 2024

Small Research Grant Program

Abstracts Alert

The Association of Women Surgeons (AWS) 2024 Annual Conference
October 18-19, 2024 | San Francisco, CA
Abstract deadline: May 30, 2024

AWS Starr Medical Student & Resident Research Forum: Calling all medical students and residents! Abstracts are limited to 300 words and must have an Introduction, Methods, Results, Conclusions, and supporting author information.

Western Surgical Association (WSA) 2024 Annual Meeting
November 2-5, 2024 | Colorado Springs, CO
Abstract deadline: June 3, 2024

Presentation Types: Oral; ePoster; Video

Southern Surgical Association (SSA) Annual Meeting
December 8-11, 2024 | Palm Beach, FL
Abstract deadline: June 30, 2024

More information can be found here: https://southernsurg.org/meeting/Abstract-Submission

Eastern Association for the Surgery of Trauma (EAST) Annual Scientific Assembly
January 14-18, 2025 | Tucson, AZ
Abstract deadline: July 1, 2024

Abstract Categories: Basic Science, Clinical Science, and Injury Prevention*.

*To be considered for the Cox-Templeton Injury Prevention Paper Competition, the Injury Abstract Category must be selected.

Department of Surgery Recent Publications

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics. (Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babic D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Baekvad-Hansen M, Borglum AD, Borte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenovic AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goleva SB, Gordon SD, Goci A, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SMJ, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljevic M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovanovic T, Karstoft KI, Kaufman ML, Kennedy JL, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kotov R, Kranzler HR, Krebs K, Kremen WS, Kuan PF, Lawford BR, Lebois LAM, Lehto K, Levey DF, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lu Y, Luft BJ, Lupton MK, Luykx JJ, Makotkine I, Maples-Keller JL, Marchese S, Marmar C, Martin NG, Martinez-Levy GA, McAloney K, McFarlane A, McLaughlin KA, McLean SA, Medland SE, Mehta D, Meyers J, Michopoulos V, Mikita EA, Milani L, Milberg W, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Mufford MS, Nelson EC, Nordentoft M, Norman SB, Nugent NR, O'Donnell M, Orcutt HK, Pan PM, Panizzon MS, Pathak GA, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Porjesz B, Powers A, Qin XJ, Ratanatharathorn A, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Runz H, Rutten BPF, de Viteri SS, Salum GA, Sampson L, Sanchez SE, Santoro M, Seah C, Seedat S, Seng JS, Shabalin A, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stensland S, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Tiwari AK, Trapido E, Uddin M, Ursano RJ, Valdimarsdottir U, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt FR, Werge T, Williams MA, Williamson DE, Winsvold BS, Winternitz S, Wolf C, Wolf EJ, Xia Y, Xiong Y, Yehuda R, Young KA, Young RM, Zai CC, Zai GC, Zervas M, Zhao H, Zoellner LA, Zwart JA, deRoon-Cassini T, van Rooij SJH, van den Heuvel LL, Stein MB, Ressler KJ, Koenen KC)

Changes in aorta hemodynamics in Left-Right Type 1 bicuspid aortic valve patients after replacement with bioprosthetic valves: An in-silico study. PLoS ONE [Electronic Resource]. (Bailoor S, Seo JH, Schena S, Mittal R)

Appendicitis Hospitalization Care Costs Among Patients With Delayed Diagnosis of Appendicitis. JAMA Network Open. (Kulasekere DA, Royan R, Shan Y, Reyes AM, Thomas AC, Lundberg AL, Feinglass JM, Stey AM)

Impact of Regional Metastasis on Survival for Patients with Nonfunctional Pancreatic Neuroendocrine Tumors: A Systematic Review. Annals of Surgical Oncology. (Clarke CN, Ward E, Henry V, Nimmer K, Phan A, Evans DB)

Racial discrimination increases the risk for nonremitting posttraumatic stress disorder symptoms in traumatically injured Black individuals living in the United States. Journal of Traumatic Stress. (Torres L, Geier TJ, Tomas CW, Bird CM, Timmer-Murillo S, Larson CL, deRoon-Cassini TA)

Pedal medial arterial calcification influences the outcomes of isolated infra-malleolar interventions for chronic limb-threatening ischemia. Journal of Vascular Surgery. (Cheun TJ, Hart JP, Davies MG)

Implementation of a countywide adult suicide review commission: Development, lessons learned, and recommendations. Suicide & Life-Threatening Behavior. (Kohlbeck SA, Schramm AT, Monroe T, Kant J, McLeod E, deRoon-Cassini TA, Hargarten SW)

Survival outcomes in pediatric patients with metastatic Ewing sarcoma who achieve a rapid complete response of pulmonary metastases. Pediatric Blood & Cancer. (Reiter AJ, Huang L, Craig BT, Davidoff AM, Talbot LJ, Coggins J, Smith J, Aldrink JH, Bergus KC, MacArthur TA, Polites SF, Boehmer C, Brungardt J, Malek MM, Rinehardt HN, Kastenberg ZJ, Arkin CM, Gourmel A, Piche N, Wallace M, Liang J, Lovvorn HN 3rd, Petroze RT, Gillies G, Marquart JP, Becktell K, Le HD, Favela J, Rich BS, Glick RD, Seemann NM, Davidson J, Wilson CA, Roach J, Brown EG, Doyle KE, Coakley BA, Emengo P, Merola P, Grant CN, Tirumani A, Tracy ET, Moya-Mendez ME, Dasgupta R, Lautz TB)

Risk Factors for Skin Flap and Nipple-Areolar Necrosis in Patients Undergoing Nipple-Sparing Mastectomy With Deep Inferior Epigastric Perforator Flap Reconstruction. American Surgeon. (Ray HR, Doren EL, Adamson K, Kong AL, Cortina CS)

The influence of home versus clinic anal human papillomavirus sampling on high-resolution anoscopy uptake in the Prevent Anal Cancer Self-Swab Study. Sexual Health. (Nitkowski J, Ridolfi TJ, Lundeen SJ, Giuliano AR, Chiao EY, Fernandez ME, Schick V, Smith JS, Brzezinski B, Nyitray AG)

Takotsubo cardiomyopathy after solid organ transplantation: a scoping review. Annals of Medicine & Surgery. (Rawashdeh B, Yaghmour N, Sulieman D, Abuassi M, Cooper M)

Thromboprophylaxis in hospitalized trauma patients: a systematic review and meta-analysis of implementation strategies. Trauma Surgery & Acute Care Open. (Ratnasekera A, Seng SS, Ciarmella M, Gallagher A, Poirier K, Harding ES, Haut ER, Geerts W, Murphy P)

Charting the Course: Insights into Neuroendocrine Tumor Dynamics in the United States. Annals of Surgery. (Wu C, Song Z, Balachandra S, Dream S, Chen H, Rose JB, Bhatia S, Gillis A)

Exploring the Association Between Structural Racism and Mental Health: Geospatial and Machine Learning Analysis. JMIR Public Health and Surveillance. (Mohebbi F, Forati AM, Torres L, deRoon-Cassini TA, Harris J, Tomas CW, Mantsch JR, Ghose R)

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