Since the start of the pandemic, there’s been plenty of talk about how we can make sure our immune system is working at its best – which has led people to try everything from taking vitamin supplements and exercising regularly to buying viral “cures” peddled online. But it turns out that one of the most significant factors in how well our immune system works is what time of day it is.

This is because our immune system is controlled by our body clock, which determines where our immune cells are in our body at different times of the day. These cells migrate around the body throughout the day, moving to our lymph nodes as we sleep to learn about what pathogens we encountered while we were awake. This field of research is still emerging but it does look like time of day can have a big impact on many aspects of immune function — from how effective our medications will be, to the severity of an infection and even how well vaccines work.

Meanwhile, the latest Conversation Weekly podcast takes a look at the health of our oceans through an exploration of the ocean economy. We ask whether exploiting this valuable resource is sustainable – and who is really paying the price. And we asked an expert who has researched slavery in the US for over 20 years to review Barry Jenkins’ TV adaptation of acclaimed novel The Underground Railroad.

Heather Kroeker

Commissioning Editor, Health + Medicine

Our body clock has evolved over millions of years to help us survive. kanyanat wongsa/ Shutterstock

How well your immune system works can depend on the time of day

Annie Curtis, RCSI University of Medicine and Health Sciences

Our immune system is controlled by our "body clock" – an intricate 24-hour system which controls how cells function.

What is a ‘blue acceleration’ doing to our oceans? Avigator Fortuner/Shutterstock

The ocean economy is booming: who is making money, who is paying the price? Podcast

Gemma Ware, The Conversation; Catesby Holmes, The Conversation; Daniel Merino, The Conversation

Plus, why Brazilian women who lived through Zika are avoiding getting pregnant during the COVID-19 pandemic. Listen to episode 18 of The Conversation Weekly podcast.

Thuso Mbedu is plays Cora in The Underground Railroad, a woman on the run to freedom in the north of the US. Kyle Kaplan/Amazon Studios

The Underground Railroad: a heartbreakingly beautiful and brutal portrayal of the journey to ‘freedom’

Rebecca Fraser, University of East Anglia

At once tender and horrific, The Underground Railroad's use of visuals and sound beautifully portray the reality of slavery and its legacy in the US today.

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