On The Cutting Edge | June 2023

June 23, 2023

Award Announcements!

Katie Iverson, MD
Assistant Professor
Division of Trauma and Acute Care Surgery

MCW Office of Global Health

FY24 Global Health Research Seed Project Funding for Faculty

Assessment of Current Surgical Data Practices in Ethiopia

Aoy Mitchell, PhD
Professor
Division of Congenital Heart Surgery

Office of Research Limited Needs Award

MicroRNA expression patterns in MYH6 tail domain variants in HLHS iPSC-CMs

Herma Heart Institute Endowment Fund/Children's Wisconsin Foundation

The Role of MYH6 and NPR3 variants in Coarctation of the Aorta

Michael Mitchell, MD
Professor; Chief
Division of Congenital Heart Surgery

Office of Research Limited Needs Award

Cell-free MicroRNA in Infant Cardiopulmonary Bypass

Please note the room change for July!

In Case You Missed It

Mentorship Database: The Division of Research is implementing initiatives to organize the process of matching research residents and medical students with faculty members for research opportunities. If you are a faculty member interested in mentoring a medical student and/or a resident, please fill out this Qualtrics survey: Survey
NIH Scientific Data Sharing Website: Whether you are involved in an NIH-funded project and want to understand which sharing policies apply to your research and how to comply, or you are a researcher looking to access scientific data from NIH-affiliated repositories, this site is for you. | More information
Grant Writing Club: Designed for anyone in the grant writing process, provides peer feedback on grants prior to or after to submission. Meets Tuesdays evenings at 5:30 PM, quarterly in the HUB6520/virtually. Participants should send a draft of their grant 1-2 weeks prior to the meeting for dissemination to peer reviewers. The club is highly interactive and participants are required to review and/or submit. Please email Rachel Morris , MD if you are interested in participating.
Department of Surgery Intranet Site: Cultural Complications/Grand Rounds/Quality Minute presentations, Surgery Sparks of Gratitude, Global Surgical Programs, Finance/Reimbursement links, DOS Phone list, and resources for logos/fonts/templates. | More Information
Abstract Deadlines and Meeting List: List will be updated each month | More Information

SurPASS Tip of the Month

Incoming Subawards

When MCW will be included in a proposal to be submitted by another institution, we refer to that as an Incoming Subaward. This is initiated by the institution outside MCW and communicated to the PI in the Department of Surgery (DOS).

Incoming subawards are reviewed by the Grants and Contracts Office (GCO). A funding proposal should be created in eBridge as a “pass-through” by the DOS Grants Operations Coordinator.

Incoming subawards are treated in the same manner as other proposal submissions. The following is needed for GCO to review an incoming subaward:

Statement of Work (SOW)
Detailed Budget
Budget Justification
RFA for application other institution is apply for
Other documents as required by the other institution

GCO will review, approve documents, and create a Letter of Intent (LOI) – a signed document to create a consortium between MCW and the other institution.

All required documents plus the LOI are submitted to the other institution by the Grants Operations Coordinator.

Any questions? Contact Lynn Cummings, Grants Operations Coordinator lcumming@mcw.edu

Clinical Research Tip of the Month

Data Use Agreement (DUA)

A DUA is a contractual agreement that covers the transfer of non-public, restricted, data. MCW requires a DUA when we provide data that:

Is HIPAA-protected or constitutes a Limited Data Set (LDS);
Contains Protected Health Information (PHI);
Was collected under a sponsored research agreement that limits disclosure of data.

When MCW is the recipient of such data, we defer to the providing organization regarding whether a DUA is required.

When MCW is providing the data, GCO prepares the DUA upon request of the MCW provider investigator and negotiates terms with the recipient organization. Once the terms are agreed upon, the MCW provider investigator signs the agreement and it is forwarded to GCO to obtain MCW institutional signature.

If you will be receiving or sharing de-identified data for human subject research, only a de-identified data agreement is required by the IRB. A template is provided and this agreement does not need to be reviewed by GCO.

GRANT$ Alert

Prevent Cancer Research Grant
$100,000/2 years
GCO deadline: July 3, 2023
Application deadline: July 11, 2023

Eligible proposals must be original and clearly describe pre-clinical, translational, clinical or population-based research projects in the field of cancer prevention or early detection. Basic science (in vitro) studies, even if meritorious, are outside the scope of this funding mechanism and will not be reviewed.

CTSI 2024 Traditional Pilot Award
$50,000/1 year (2 awards available)
Letter of Intent due: July 7, 2023
GCO deadline: August 24, 2023 (eBridge)
Application due: September 1, 2023 (REDCap)

These awards are intended to stimulate inter-institutional and interdisciplinary/multidisciplinary clinical and translational research among the CTSI partner institutions. In supporting such collaboration, these Pilot awards promote and support best practices in team science research.

American Cancer Society - Clinical Research Professor Award
$80,000/year for 5 years
Letter of Intent due: August 1, 2023
GCO deadline: October 8, 2023
Application due: October 15, 2023

Grant for investigators who have the rank of full professor and made seminal contributions in the area of cancer control that have changed the direction of clinical, psychosocial, behavioral, health policy, or epidemiologic cancer research.

Mellowes Center Mini-Grants - Sequencing, Bioinformatics, and Analysis
18 hours of Mellowes Center bioinformatics analytics services
Up to 10 eligible projects will be funded annually

Small-scale research projects will receive 18 hours of Mellowes Center bioinformatics analytics services.

AHW MCW-Led Learning Event Support Funding
$5,000 per learning event
Application accepted until December 31, 2023 as long as funding remains available

Rolling first-come, first serve basis.

Herma Heart Institute Seed Money
$10,000 one-time request
Proposal due in eBridge: N/A
Application due: Reviewed quarterly

Must have an HHI faculty member as the PI or co-PI.

Abstracts Alert

The Southern Surgical Association (SSA) Annual Meeting
December 3-6, 2023 | Hot Springs, VA
Abstract deadline: June 30 , 2023

Abstract submission information can be found here: https://www.southernsurg.org/Submissions.aspx

Eastern Association for the Surgery or Trauma (EAST) Annual Scientific Assembly
January 9-13, 2023 | Orlando, FL
Abstract deadline: July 1, 2023

Abstract Categories:
Basic Science - abstract would include bench research that involves laboratory studies with cell cultures, animal models or physiologic experiments.

Clinical Science - abstract would include the use of randomized controlled trials, observational trials, retrospective studies, database analysis involving humans/human samples that examine disease/ diagnostics/ drugs/ devices/biologics or outcomes. Clinical Case Reviews or Series are not permitted.

Injury Prevention - abstract would include primary prevention, secondary prevention, and tertiary prevention, along with education strategies, engineering strategies and behavioral studies. See category requirement below for Cox-Templeton Injury Prevention Paper Competition.

The Society of Thoracic Surgeons (STS) 60th Annual Meeting
January 27-29, 2024 | San Antonio, TX
Abstract deadline: July 20, 2023

Submissions of abstracts, "How I Do It" surgical videos, and session proposals are being accepted now. More information can be found here: https://www.sts.org/abstract-submission

Society of Critical Care Medicine (SCCM) Critical Care Congress
January 21-23, 2024 | Phoenix, AZ
Abstract deadline: August 2, 2023

Eligibility Requirements 
Abstracts, case reports, and/or data previously presented or published nationally or internationally are not allowed.
Abstracts and case reports presented at an SCCM chapter meeting are allowed.
Abstracts and case reports may contain new research on a topic presented previously.
Submission of an abstract or case report constitutes a commitment by the author(s) to present the abstract or case report as accepted.
Stimulating and unique abstracts or case reports will be considered for the 2024 Congress program.

Department of Surgery Recent Publications

Experiencing racial discrimination increases vulnerability to PTSD after trauma via peritraumatic dissociation. European Journal of Psychotraumatology. (Harb F, Bird CM, Webb EK, Torres L, deRoon-Cassini TA, Larson CL)

Going for Broke: The Impact of Cost of Living on Surgery Resident Stipend Value. Annals of Surgery. (Drezdzon MK, Cowley NJ, Sweeney DP, Peterson CY, Ridolfi TJ, Ludwig KA, Evans DB, Calata JF)

Bridging the Gap: Trainee Reflections About Navigating Otherness in Academic Surgery. Journal of Surgical Research. (SenthilKumar G, Verhagen NB, Wang TS, Dream SY, Kothari AN)

Mental Health and Health-Related Quality of Life After Firearm Injury: A Preliminary Descriptive Study. Annals of Internal Medicine. (Timmer-Murillo SC, Melin SJH, Tomas CW, Geier TJ, Brandolino A, Schramm AT, Larson CL, deRoon-Cassini TA)

Online medical education: A student survey. The Clinical Teacher. (Faria I, Moura CB, Graner M, Campos LN, Gerk A, Bittencourt MM, Cazumba ML, Mishaly A, Buda AM, Truche P, Bowder AN, Botelho F, Carroll M, Mooney D, Naus A)

Altered Contractility, Ca2+ Transients, and Cell Morphology Seen in a Patient-Specific iPSC-CM Model of Ebstein's Anomaly with Left Ventricular Noncompaction. American Journal of Physiology - Heart & Circulatory Physiology. (Thareja SK, Anfinson M, Cavanaugh M, Kim MS, Lamberton P, Radandt J, Brown R, Liang HL, Stamm KD, Afzal MZ, Strande JL, Frommelt MA, Lough JW Jr, Fitts RH, Mitchell ME, Tomita-Mitchell A)

Quantifying the impact of reduced opioid use in patients after emergency laparotomy. Surgery. (Tchen S, Bhatt R, Peppard W, Szabo A, Dong H, Morris R, Trevino CM)

Preparing for and passing the fundamentals of laparoscopic surgery (FLS) exam improves general surgery resident operative performance and autonomy. Surgical Endoscopy. (Higgins RM, Turbati MS, Goldblatt MI)

Trichobezoar: A Rare Cause of Protein-losing Enteropathy. JPGN Reports. (Bashir A, Tejada AG, Oldham KT, Thakrar PD, Lerner DG)

Implementation of a culturally competent APOL1 genetic testing programme into living donor evaluation: A two-site, non-randomised, pre-post trial design. BMJ Open. (Smith JD, Agrawal A, Wicklund C, Duquette D, Friedewald J, Rasmussen LV, Gacki-Smith J, Tandon SD, Muhammad LN, Yancy CW, Dong S, Cooper M, Gilbert A, Shetty A, Gordon EJ)

Management and Outcomes of Wilms Tumor with Suprarenal Intravascular Extension: A Pediatric Surgical Oncology Research Collaborative Study. Annals of Surgery. (Naik-Mathuria B, Utria AF, Ehrlich PF, Aldrink JH, Murphy AJ, Lautz T, Dasgupta R, Short SS, Lovvorn HN 3rd, Kim ES, Newman E, Lal DR, Rich BS, Piche N, Kastenberg ZJ, Malek MM, Glick RD, Petroze RT, Polites SF, Whitlock R, Alore E, Sutthatarn P, Chen SY, Wong-Michalak S, Romao RL, Al-Hadidi A, Rubalcava NS, Marquart JP, Gainer H, Johnson M, Boehmer C, Rinehardt H, Seemann NM, Davidson J, Polcz V, Lund SB, McKay KG, Correa H, Rothstein DH)

History of Racial Discrimination by Police Contributes to Worse Physical and Emotional Quality of Life in Black Americans After Traumatic Injury. Journal of Racial & Ethnic Health Disparities. (Geier TJ, Timmer-Murillo SC, Brandolino AM, Pina I, Harb F, deRoon-Cassini TA)

Undertriage of Severely Injured Trauma Patients. American Surgeon. (Anderson K, Schellenberg M, Owattanapanich N, Dunkelberger L, Wong MD, Morris RS, Demetriades D)

The impact of frailty on outcomes following laparoscopic repair of ‘giant’ paraesophageal hernias. Surgical Endoscopy. (Xu TQ, Maguire J, Gould J)

Validation of the AJCC 8th Edition Staging System for Disseminated Appendiceal Cancer Patients Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Multi-institutional Analysis. Annals of Surgical Oncology. (SenthilKumar G, Kothari AN, Maduekwe UN, Fournier K, Abbott DE, Wilson GC, Patel SH, Greer J, Johnston F, Dineen SP, Powers BD, Baumgartner J, Veerapong J, Leiting J, Grotz TE, Maithel SK, Staley C, Raoof M, Lambert L, Lee A, Kim A, Cloyd JM, Mogal H)

3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease. Frontiers in Cardiovascular Medicine. (Wolfe JT, He W, Kim MS, Liang HL, Shradhanjali A, Jurkiewicz H, Freudinger BP, Greene AS, LaDisa JF Jr, Tayebi L, Mitchell ME, Tomita-Mitchell A, Tefft BJ)

Assessing surgical risk calculators on hernia repair candidates with cirrhosis. Hernia. (Xu SY, Jackson J, Goldblatt MI)

Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient. World Journal of Surgery. (Peden CJ, Aggarwal G, Aitken RJ, Anderson ID, Balfour A, Foss NB, Cooper Z, Dhesi JK, French WB, Grant MC, Hammarqvist F, Hare SP, Havens JM, Holena DN, Hubner M, Johnston C, Kim JS, Lees NP, Ljungqvist O, Lobo DN, Mohseni S, Ordonez CA, Quiney N, Sharoky C, Urman RD, Wick E, Wu CL, Young-Fadok T, Scott MJ)

Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS R) Society Recommendations Part 2-Emergency Laparotomy: Intra- and Postoperative Care. [Review]. World Journal of Surgery. (Scott MJ, Aggarwal G, Aitken RJ, Anderson ID, Balfour A, Foss NB, Cooper Z, Dhesi JK, French WB, Grant MC, Hammarqvist F, Hare SP, Havens JM, Holena DN, Hubner M, Johnston C, Kim JS, Lees NP, Ljungqvist O, Lobo DN, Mohseni S, Ordonez CA, Quiney N, Sharoky C, Urman RD, Wick E, Wu CL, Young-Fadok T, Peden CJ)

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