WHO invites makers of mpox tests for emergency review in push for rapid access
Reuters (8/29)
On Thursday, the World Health Organization (WHO) asked manufacturers to submit mpox diagnostic tests for emergency review in an effort to speed up and broaden access to effective testing amid the mpox emergency on the African continent. WHO has also updated its mpox testing guidance and is working with countries to roll out testing, with 30,000 tests expected to arrive in African countries in the coming weeks. Manufacturers Labcorp and Roche have also said that they are working to increase their mpox testing capacity.
CEPI partners with Afrigen to speed up mRNA vaccine development and access
CEPI press release (8/26)
The Coalition for Epidemic Preparedness Innovations (CEPI) will provide $2.05 million to South African biotech company Afrigen Biologics for a proof-of-concept project to investigate whether synthetic DNA could serve as an alternative to the traditional plasmid DNA used for mRNA vaccine development, cutting timelines and costs. The partnership supports the 100 Days Mission of reducing vaccine development timelines to just 100 days after identifying a disease outbreak with pandemic potential. The project could help further optimize mRNA vaccine development—which is already much faster and more flexible than traditional vaccines—in the face of an outbreak, as well as enable local manufacturing of vaccines in Africa, which could help facilitate more equitable access to vaccines.
First-ever Phase 2 Lassa vaccine clinical trial now fully active across West Africa
IAVI feature (8/26), features CEPI
Last week, IAVI announced that the first participants at trial sites in Ghana, Liberia, and Nigeria had been vaccinated in a clinical trial of IAVI’s Lassa fever candidate. Lassa fever, for which there is limited treatment and no available vaccine, causes an estimated 300,000 cases across West Africa annually, and the threat is expected to grow due to climate change and population growth. The trial, funded by CEPI and designed in consultation with in-country partners, will evaluate the candidate’s safety, tolerability, and immunogenicity at two different dosage levels in adults, including people living with HIV, as well as in adolescents and children two years and older. The trial results are expected in 2025.
