Transfusion Evidence Round-Up

Bleeding Disorders: World Haemophilia Day 2023

Welcome to the quarterly Transfusion Evidence Round-Up. This is a collaboration between the International Society of Blood Transfusion (ISBT) and the Transfusion Evidence Library (TEL).  We aim to highlight high quality evidence randomised controlled trials and systematic reviews about an internationally relevant subject in the field of Transfusion Medicine.  All references are drawn from the Transfusion Evidence Library and, where relevant, Stem Cell Evidence.

This Transfusion Evidence Round-Up is sent to ISBT members and TEL subscribers, so if you are a subscriber to both mailing lists and receive it twice please bear with us until we can resolve this.

The Transfusion Evidence Library is produced by the Systematic Review Initiative (SRI) and funded by the four UK blood services. It is available free at the point of access providing a comprehensive and up-to-date database of high quality evidence in Transfusion Medicine.

The International Society of Blood Transfusion (ISBT) is a scientific society creating a community of transfusion medicine professionals from around the globe. ISBT works towards its vision of "a world of safe and sufficient blood" by undertaking advocacy for patient and donor safety, sharing knowledge to enhance transfusion practice and providing opportunities for education.

Top Article

Platelet-to-red blood cell ratio and mortality in bleeding trauma patients: A systematic review and meta-analysis.
Kleinveld, D.J.B., et al. (2021). Transfusion.
PICO SUMMARY

Selected Articles

IVMP+IVIG raises platelet counts faster than IVIG alone: results of a randomized, blinded trial in childhood ITP.
Carcao, M., et al. (2020). Blood Advances.

Effects of replacement therapies with clotting factors in patients with hemophilia: A systematic review and meta-analysis.
Delgado-Flores, C.J., et al. (2022). PlosOne.

Comparative efficacy and safety of thrombopoietin receptor agonists in adults with thrombocytopenia: A systematic review and network meta-analysis of randomized controlled trial.
Deng, J., et al. (2021). Frontiers in Pharmacology.

Risk factors for bleeding in people living with Hemophilia A and B treated with regular prophylaxis: a systematic review of the literature.
Germini, F., et al. (2022). Journal of Thrombosis and Haemostasis.

The impact of recombinant versus plasma-derived factor VIII concentrates on inhibitor development in previously untreated patients with hemophilia A: A 2021 update of a systematic review and meta-analysis.
Kohar, K., Prayogo, S.A., and Wiyono, L., (2022). Cureus.

Pre-procedural use of thrombopoietin-receptor agonists in cirrhosis and severe thrombocytopenia: A systematic review and meta-analysis.
Rose, P.D., et al. (2021). Digestive and Liver Disease.

Risk of thrombosis with thrombopoietin receptor agonists for ITP patients: a systematic review and meta-analysis.
Tjepkema, M., Amini, S., and Schipperus, M., (2022). Critical Reviews in Oncology/Hematology.

Comparative efficacy of 19 drug therapies for patients with idiopathic thrombocytopenic purpura: a multiple-treatments network meta-analysis.
Zhou, H., et al. (2022). Annals of Hematology.

Incidence and mortality rates of intracranial hemorrhage in hemophilia: a systematic review and meta-analysis.
Zwagemaker, A.F., et al. (2021). Blood.

Join the Live Journal Club to discuss these top 10 papers on Thursday, 9^th March at 09:00 AM (CET). Register here: https://www.isbtweb.org/events/sri-isbt-live-journal-club-transfusion-evidence-round-up-world-haemophilia-day-2023.html

The webinar is free and open to all.

Editorial Board, Transfusion Evidence Round-Up, March 2023

Dr. Lyuben Georgiev - Bulgaria
Dr. Lyuben Georgiev, is a first-year resident physician at the National Center of Transfusion Hematology in Bulgaria, Department of Blood Supply Management. Member of the Bulgarian Scientific Society of Transfusion Hematology.
His research experience includes 2 case study presentations at student congresses. More recently, he worked on manuscript preparation for a large database study on multiple myeloma conducted at Hackensack University Medical Center, USA. He also took several online research courses, by Medical Research Academy and Nature Masterclasses.

Jessica Guglielmino - Australia
Jessica Guglielmino is a blood bank and haematology medical scientist at Monash Medical Centre in Melbourne, Australia. Graduated with a Masters of Laboratory Medicine from RMIT University, she is passionate about all aspects of immunohematology and transfusion science. She is also a research scientist within Monash University’s Transfusion Research Unit (TRU). Jess is an active member of numerous professional societies, including the International Society of Blood Transfusion (ISBT), the Australian & New Zealand Society of Blood Transfusion (ANZSBT) and the Australian Institute of Medical and Clinical Scientists (AIMS).

Professor Gesine Weckmann - Germany
Gesine Weckmann is a physician and completed her transfusion medicine residency at the university of Rostock.
She is currently working as a professor for health education and prevention with a research focus on Health services research and anemia.
Member of the German Society of Transfusion Medicine and ISBT.