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Welcome to the March 2025 edition of the Rare Mutations and Fusions newsletter from LUNGevity's Patient Gateways.

Since our last newsletter in September, we have seen a lot of progress in the lung cancer space—including the US Food and Drug Administration’s (FDA’s)  first approval for treating NRG1-positive non-small cell lung cancer (NSCLC) with zenocutuzumab.

In addition, the FDA has agreed to expedite the review process for using zongertinib to treat adults with advanced, HER2-positive NSCLC. Meanwhile, other studies are underway to expand the use of trastuzumab deruxtecan to treat NSCLC tumors that have overexpression of HER2.

Taletrectinib, an oral drug with central nervous system activity, has also been granted an accelerated review by the FDA for treating advanced ROS1-positive NSCLC.

The progress in the lung cancer space for many different types of rare mutations and fusions has been exciting, as exemplified by our advances in treating RET-positive NSCLC. These types of research studies must continue so that patients with lung cancer can get access to the next generation of treatments on the horizon.

Research News

OncLive
Zongertinib Displays Early Activity and Tolerability in HER2-Mutated Solid Tumors
Published Mar 10, 2025

OncLive
Zenocutuzumab Addresses High Unmet Need in NRG1-Positive NSCLC and Pancreatic Cancer
Published Jan 16, 2025

ReachMD
Targeting HER2-Mutant NSCLC with Trastuzumab Deruxtecan: Initial Study Findings
Published Jan 15, 2025

OncLive
Unmet Needs and Future Perspectives of RET-Positive NSCLC
Published Jan 15, 2025

CURE
FDA Accepts New Drug Application For Taletrectinib in ROS1+ NSCLC
Published Jan 4, 2025

Delve Insight
Evolving Landscape for Rare Biomarkers in Non-Small Cell Lung Cancer
Published Nov 29, 2024

Get Connected

You Are Invited!   
Ready to experience an event that’s all about YOU? HOPE Summit is where lung cancer survivors and caregivers come together to connect, learn, and thrive. Think of it as a weekend filled with inspiration, knowledge, and a whole lot of hugs and high-fives. This year's event takes place May 2-4 in Bethesda, MD, and is free to attend. Registration is now open! Learn more. 

 

New Hope for Treating RET+ Cancers: A Live Discussion 

Discover groundbreaking cancer research! Join our Facebook Live event to explore protein degraders, a promising new approach for treating RET-positive cancer. Hear from patient advocates and experts, including Justin Drake, PhD, a leading researcher at the University of Minnesota. Dr. Drake, the 2024 RETpositive/LUNGevity awardee, will explain how these innovative therapies work, offering hope for those with RET-driven cancers. We hope to see you on March 28 at 12-1 pm ET at Facebook.com/LUNGevity.

Join Us for the Rare Mutations Virtual Meetup 
This is an easy way to build your community. On the first Wednesday of each month, you can connect with others who understand what it’s like to live with lung cancer with rare mutations and fusions. The next Rare Mutations Meetup is happening on Wednesday, April 2, at 3 pm ET.

Register for this virtual meetup to get a confirmation email with details about how to join the virtual meeting. New attendees are always welcome and encouraged to join! Can’t make it? Don’t worry, there’s a full list of virtual meetups to fit your schedule.

 

Have You Seen?

Brain Mets Basics for NSCLC   
Learn all about brain metastases in NSCLC from an expert in the field. Don’t miss the sections dedicated to treating brain mets in people with rare lung cancer biomarkers, including MET, NTRK, RET and ROS1. Watch here.

Significant Weight Loss During Treatment  
Losing significant weight and muscle mass during lung cancer treatment is common. However, often these symptoms are not a side effect of treatment. They can be due to a condition called cachexia. Learn more about this condition—including who is at risk for it, how to recognize it, and what can be done to address the symptoms.

Treatment News for RET+ NSCLC 
Learn about FDA-approved treatments for RET-positive lung cancer from John Heymach, MD, PhD, an internationally acclaimed physician-scientist, who also discusses important research in the field. In this panel discussion, patient advocates share their perspectives on how everyone with lung cancer has something to contribute—their experiences! Watch here.

Understanding Clinical Trials: Three-Part Series    
This series on clinical trials explains how drugs get approved by the FDA and become available to you.

Part 1: Why Are Clinical Trials Important for Drug Development?

Part 2: How Do We Define Success for Clinical Trials? 

Part 3: How Do Drugs Get Approved (and Fast-Tracked) by the FDA?

… and there is always so much more to explore on the Rare Mutations & Fusions Patient Gateway.

If you were forwarded this email and you’d like to subscribe to this newsletter, you can sign up here.

If you are looking for more LUNGevity Foundation news, check out LUNGevity’s monthly newsletter.

If you need further assistance along your lung cancer journey, please email us at support@lungevity.org. Our team is always here to assist you.

 
 
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LUNGevity Foundation

228 S. Wabash, Suite 700, Chicago, IL 60604

6917 Arlington Road, Suite 352, Bethesda, MD 20814

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